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高频振荡通气并西地那非治疗新生儿持续肺动脉高压临床研究 被引量：9

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摘要 西地那非是5型磷酸二酯酶（PDE5）抑制剂，在动物模型和成人研究中发现，其抑制PDE降解环磷酸鸟苷（cGMP）生成磷酸鸟苷，使cGMP水平升高，引起肺动脉血管舒张，可选择性降低肺血管阻力。近年研究发现，新生儿出生后肺动脉PDE5是一氧化氮（NO）诱导血管舒张的关键调节因子，PDE5抑制剂能使肺血管舒张，即使缺乏对外源性NO有反应的内皮细胞，西地那非亦可有效降低肺动脉压力和肺血管阻力。高频震荡通气（HFOV）是一种特殊的通气方式，能以极高的频率、极小的潮气量迅速改善氧合和通气效率。
作者 张璋 孙慧清 张雨
机构地区 郑州市儿童医院新生儿科
出处 《中国新生儿科杂志》 CAS 2010年第6期360-362,共3页 Chinese Journal of Neonatology
关键词 新生儿持续肺动脉高压 西地那非 高频振荡通气 临床研究 PDE5抑制剂 肺血管舒张 5型磷酸二酯酶 环磷酸鸟苷
分类号 R722.1 [医药卫生—儿科]
  • 相关文献

参考文献8

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二级参考文献30

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共引文献24

同被引文献38

  • 1宁岑,杨杰,向建文.高频震荡通气治疗新生儿肺透明膜病[J].实用诊断与治疗杂志,2006,20(6):408-409. 被引量：4
  • 2邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].第4版.北京:人民卫生出版社,2011:872.
  • 3邵肖梅,叶鸿瑶,丘小汕.实用新生儿学[M].4版.北京:人民卫生出版社,2011:807-808.
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  • 6Michelakis E, Tymchak W, Lien D, et al. Oral sildenafil is an effec- tive and specific pulmonary vasodilator in patients with pulmonary arterial hypertensiorl : comparison with in-haled nitric oxide [ J ]. Cir- culation ,2002,105 (20) :2398-2403.
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  • 10黄国英.一氧化氮治疗新生儿持续肺动脉高压[J].广东医学,2013,17(2):128-150.

引证文献9

二级引证文献36

中国新生儿科杂志
2010年 第6期

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