摘要
研究自的 探讨小儿喘息性疾病与血浆环核苷酸变化的关系。 研究设计 病例对照研究。 患者和其他参与者 支气管哮喘(哮喘)患者25例,哮喘性支气管炎(哮支)21例,毛细支气管炎(毛支)25例。对照组60例,均为正常健康儿童。 处理方法 所有患者和参与者均于晨8～10时采血,用放射免疫分析法检测血浆cAMP、cGMP,并计算cAMP/cGMP的比值。 主要结果 正常儿童血浆cAMP和cGMP的含量与年龄无关。对照组、哮喘组、哮支组和毛支组cAMP水平分别为21.483±6.635、14.80±3.449、17.366±5.430和18.344±5.159nmol/L,cGMP分别为3.406±0.919、4.468±1.22、4.32±1.497和4.264±1.20nmol/L。各疾病cAMP、cGMP水平和cAMP/cGMP的比值与对照组相比均有显著性差异。 结论 血浆cAMP降低,cGMP升高,cAMP/cGMP比值下降,不仅是哮喘发作的重要原因,而且也与哮支、毛支的喘息发作有关。
Objective To search for the relationship between asthmatic diseases and the changes of cyclic nucleotidein children. Design Case-control research. Patients and Other Participants There are 25 patients with hronchial asthma, 21 patients with asthmaticbronchitis and 25 patients with bronchiolitis. There are 60 healthy children in control group. Interventions The blood of all of the patients and other participants had been drawn at 8～10 o,clockin the morning. Plasma cAMP. cGMP had been determined by radioimmunoassay and the values of cAMP/cGMP had been shown. Main Results There are no relationship between the levels of cAMP. cGMP and the age in kealth chi-ldren. The levels of cAMP in control group. bronchial asthma group. asthmatic bronchitis group and bron-chiolitis group are 21.483±6.635, 14.80±3.449、17.366±5。430 and 18.344±5.159 nmol/L respectively, the cGMP levels are 3.406±0.919、4.468±1.22、4.32±1.497 and 4.264±1. 20nmol/L. The levels of cAMPcGMP and the values of cAMP/cGMP in all of the disease group have significance difference comparingwith control group. Conclusions Decreased levels of cAMP and the values of cAMP/cGMP, increased levels of cGMP arenot only a important reason of asthma attack, but also the asthmatic bronchitis and bronchiolitis.
出处
《实用儿科临床杂志》
CAS
CSCD
1992年第4期171-174,共4页
Journal of Applied Clinical Pediatrics
