摘要
目的评价美罗培南与万古霉素联用治疗实体瘤患儿自体外周血干细胞移植过程中合并中重度感染的临床疗效及安全性。方法剂量为美罗培南10～20mg／（kg·次），万古霉素10～20mg／（kg·次），均为1次／12h静脉滴注。结果美罗培南与万古霉素联用有效率为78．4％，4例合并败血症患儿中2例有效，不良反应发生率为8．1％。结论关罗培南与万古霉素联用治疗自体外周血干细胞移植过程中合并中重度感染疗效显著，而且安全性好。
Objective To study the therapeutic effect and safety Vancomycin in children who had severe infection during autologous peripheral of Meropenem combined with blood stem cell transplantation （APBSCT） for malignant solid tumors. Methods A retrospective study was analyzed on 37 cases of malignant solid tumors complicated with severe infection during APBSCT. They were treated with Meropenem and Vancomycin in a dose of 10 -20 mg/kg, q 8 - 12 h and 20 -30 mg/kg, q 8 - 12 h, respectively. Results The total effective rate was 78.4%. Among 4 cases complicated with septicemia, 2 were effective. The incidence rate of adverse effect was 8.1%. Conclusion Combination of Meropenem with Vancomycin was effective and safe in the treatment of solid tumor children with severe infection during APBSCT.
出处
《中国小儿血液与肿瘤杂志》
CAS
2010年第5期215-217,共3页
Journal of China Pediatric Blood and Cancer
关键词
美罗培南
万古霉素
实体瘤
感染
外周血干细胞移植
Meropenem
Vancomycin
Solid tumor
Infection
Peripheral blood stemcell transplantation
