摘要
目的:探讨化疗引起Ⅳ度骨髓抑制的治疗方法。方法:对268例恶性肿瘤患者288例/次因化疗引起Ⅳ度骨髓抑制的治疗方法进行总结与分析。结果:绝对中性粒细胞计数(ANC)<0.5×109·L-1出现的中位时间为化疗后至第9天,12例/次血小板最低至5×109～24×109·L-1,6例/次血红蛋白最低至5～6.4g·100mL-1,37例/次预防使用抗菌药物无效后改用三线抗生素或联用抗生素才控制感染;12例/次在住院期间ANC没有恢复正常。结论:对于化疗后Ⅳ度骨髓抑制患者,及时采取保护性隔离,应用粒细胞集落刺激因子、抗菌药物及支持治疗等综合处理,患者基本可安全度过化疗的危险阶段。
OBJECTIVE：To observe the occurrence of severe myelosuppression after chemotherapy and to improve its therapeutic effects. METHODS：A total of 288 cases of 268 patients with grade Ⅳ bone marrow suppression induced by chemotherapy treatment were analyzed. RESULTS：Of the 288 cases,The median day when absolute neutrophil coun（tANC）0.5×109·L-1 was the 9th day. Twelve cases had grade Ⅳ thrombocytopenia between 5×109～24×109·L-1 and 6 cases had grade Ⅳ hemoglobin decrease 5～6.4 g·100 mL-1. After preventive antibiotics were unsuccessfully applied in 37 cases,thirdline antibiotics were used to control the infection;the white blood cell（ANC）level of 12 cases did not recover during their hospitalization. CONCLUSION：If combined treatment such as being isolated in a strictly sterilized room in time as well as offering GCSF,antibiotic drugs and proper supportive treatment,patients with grade Ⅳ myelosuppression could safely get through the dangerous chemotherapy period.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第14期1310-1312,共3页
China Pharmacy
关键词
化疗
骨髓抑制
粒细胞集落刺激因子
抗菌药物
Chemotherapy
Bone marrow suppression
Granulocyte colony-stimulating factor
Antibiotics
