摘要
本研究采用学习记忆行为训练和生化测定的方法，观察了我国４种常见海蛇的乙醇浸出物（ＡｌｃｏｈｏｌｉｃＥｘｔｒａｃｔｓｏｆＢｏｄｉｅｓｏｆＳｅａ Ｓｎａｋｅ．ＡＥＢＳＳ）对小鼠的正常学习记忆、东莨菪碱（Ｓｃｏｐｏｌａｍｉｎｅ，Ｓｃｏｐ）所致记忆障碍、脑不同部位蛋白质含量的影响。结果表明，ＡＥＢＳＳ（剂量５００ｍｇ浸出蛋白／ｋｇ体重以上）对正常小鼠的学习记忆能力及脑内蛋白质合成有明显的促进作用；ＡＥＢＳＳ还能极显著地改善Ｓｃｏｐ所致的学习记忆障碍，使Ｓｃｏｐ组大脑皮层和小脑的蛋白质含量显著增加，海马脑区的蛋白质含量增加极显著。结果提示，ＡＥＢＳＳ对小鼠学习记忆的作用机制可能与中枢胆碱能递质系统的蛋白质合成有关。
Effects of alcoholic extracts of bodies of sea snake (AEBSS) on the capacity of learningand memory of rats were studied by using learning-behavioral training and biochemical determi- nation. The results showed that the AEBSS improved the capacity of learning and memory ofnormal rats (P O. 05), and prevented the memory dysfunction induced by Scopolamine( 0.01); the contents of brain protein were increased by AEBSS in both normal rats ( 0. 05 )and the rats of Scop-group( 0. 05 or 0. 01 ). The results suggested that the effects ofAEBSS on the capacity of learning and memory of rats may be pelated to the protein synthesesof cholinergic transmitter system in the brain.
出处
《黄渤海海洋》
CSCD
1999年第2期48-52,共5页
Journal of Oceanography of Huanghai & Bohai Seas
关键词
海蛇
乙醇浸出物
学习记忆
小鼠
海蛇体制剂
Alcoholic extracts of bodies of sea snake (AEBSS),Learning and memory
