摘要
目的探讨多囊卵巢综合征(PCOS)患者子宫内膜形态和病理改变及其与性激素和肥胖的关系。方法 12例PCOS不孕患者(PCOS组)经过促排卵治疗后,与7例健康妇女对照组(自然周期)均在着床窗口期观察子宫内膜超声形态学改变,同时取子宫内膜活检观察其病理状态,并研究其与性激素、肥胖的关系。结果 (1)研究对象子宫内膜病理比较:PCOS组间质反应不良和分泌反应欠佳发生率均高于健康对照组,差异有统计学意义(P<0.05)。(2)超声观察着床窗口期子宫内膜厚度,PCOS组略低于健康对照组,但差异无统计学意义(P>0.05);A型内膜出现率,PCOS组低于健康对照组,差异有统计学意义(P<0.05)。结论 PCOS患者子宫内膜的形态和病理均发生了改变,导致子宫内膜容受性缺陷,从而影响胚胎着床。
Objective To investigate the ultrasonic and pathological characteristics of the endometrium and the relationship with sexual hormones,obesity index in polycystic ovary syndrome（PCOS） patients.Methods Endometrium biopsy was done in the 12 PCOS patients received ovulation induction therapies and the seven nomal women with regular menstruation during implanting window time.then to study the ultra-sonic and pathology features of endometrium.Results（1）Routine HE staining of endometrium：there was significant difference of percentage of endometrial sample with poor response of stroma and secretion deficiency between PCOS patients and control group（P〈0.05）.（2）The endometrial thickness of PCOS patients was slightly lower than that of control group,but there was no significant difference（P〈0.05）.The frequency of type A endometrium,PCOS patients was significantly lower than that of control group（P〈0.05）.Conclusion There are significant changes in features and function of PCOS endometrium,which induce the defect of endometrial receptivity.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第21期2931-2933,共3页
Chongqing medicine
基金
三峡大学青年科学基金资助项目(KJA0462)
