摘要
目的：在呼吸门控下采用螺旋ＣＴ定量测定肺密度，并与临床肺功能对照，研究肺部病变形态与功能的相互关系。材料与方法：对照组２０例和病变组４０例行临床肺通气功能检查和呼吸门控下螺旋ＣＴ扫描。ＣＴ扫描在５０％肺活量水平以８ｍｍ层厚进行。应用评估软件测定上、中、下肺区平均ＣＴ值及象素的频率分布（即象素指数）。分析它们在对照组和病变组之间的差异及与肺通气功能的相关性。结果：ＣＴ上有形态异常可表现为肺通气功能正常（Ｎ组）、限制性（Ｒ组）和混和性通气功能障碍（Ｒ＆Ｏ组），各组的平均ＣＴ值与对照组有显著性差异（Ｐ＜０．０１）。Ｒ组的象素分布曲线波峰降低并右移，Ｒ＆Ｏ组象素分布曲线低平、波幅增宽。６０例肺平均ＣＴ值与肺通气功能无相关性，但区间Ａ（－１０２４～－９０１ＨＵ）、Ｂ（－９００～－８０１ＨＵ）、Ｄ（≥－７００ＨＵ）的象素与后者相关（分别为ｒ＝－０．５７，Ｐ＜０．０１；ｒ＝０．６８，Ｐ＜０．０１；ｒ＝－０．６１，Ｐ＜０．０１）。结论：根据ＣＴ形态学表现、平均ＣＴ值和象素分布特点，可在获得形态学诊断的同时大致评估肺通气功能状态。
Objective: To study the correlation of pulmonary morphologic changes and ventilation function by quantitatively measuring of pulmonary density with spirometrically controlled spiral CT scanning and comparing pulmonary density values with clinical ventilation function. Materials and Methods: Clinical pulmonary ventilation function test and spiral CT scan controlled by spirometer were performed in 20 healthy adults and 40 patients. Spiral CT scan was obtained at 50% vital capacity (VC) with 8mm slice thickness. The average attenuation values and their frequency distribution (i.e. pixel index,PI) of superior, middle and inferior lung regions were measured with semiautomatic evaluation software. The difference between the control group and the study group and its relationship with the ventilation function were analyzed. Results: Patients with pulmonary morphologic abnormalities on CT scans represented, clinically, normal ventilation function (N group), restrictive lung function (R group) or restrictive and obstructive lung function (R&O group). Significant difference of mean CT values was seen between the control group and the above three groups ( P< 0.01). On the pixel distribution histograms of R group patients, the curve peak was lowed and shifted to the right. While in R&O group patients, the curve peak was low and wide. The average pulmonary CT values of 60 cases showed no relationship with clinical ventilation function, though pixel index of interval A (-1024-901HU), B (-900-801HU), and D (-700HU) showed a high correlation with clinical ventilation function, with r=-0.57 (P<0.01), r=0.68 (P< 0.01) and BXr=-0.61 (P< 0.01), respectively. Conclusion: Based on the morphologic appearance, mean CT values and pixel index, morphologic diagnosis can be made and pulmonary ventilation function can be approximately evaluated simultaneously.
出处
《临床放射学杂志》
CSCD
北大核心
1999年第6期337-342,共6页
Journal of Clinical Radiology
基金
卫生部科研基金
