摘要
目的探讨survivin在分化型甲状腺癌发生发展中的作用及与微血管生成的关系。方法采用免疫组织化学检测56例分化型甲状腺癌组织和10例正常甲状腺组织survivin和CD34的表达,并计数微血管密度(MVD),分析分化型甲状腺癌中survivin的表达与血管生成的关系。结果甲状腺癌组织中survivin蛋白阳性率为75%(42/56),正常甲状腺组织中无表达。survivin蛋白在肿瘤组织中的表达与临床分期,颈淋巴结转移,原发灶的包膜侵犯均显著相关。在甲状腺癌组织中,随survivin表达增强,MVD逐渐增高,呈正相关。结论 survivin蛋白在分化型甲状腺癌组织中表达上调,并与微血管生成关系密切,提示survivin与甲状腺癌的发生、发展有关。
Objective To evaluate the relationship between survivin expression and angiogenesis as well as clinicopathological characteristics of differentiated thyroid carcinoma DTC through analysing the expression of survivin and microvessel density（MVD） of DTC.Methods Survivin and CD34 expressions were examined immunohistochemically in tissue samples from 56 DTC patients and 10 normal cases.Meantime,the relationship between expressions of survivin and CD34 and clinicopathological characteristics of patients were analyzed.Results Expression rate of survivin protein was 75%（42/56） in DTC,and survivin was negative in 10 normal thyroid tissues.Expression rate of survivin was significantly related to the advanced DTC,and cN＋ DTC,and the DTC with extracapsular invasion.The MVD was significantly higher in DTC than that in normal thyroid tissue.Conclusion The Survivin expression and MVD were upregulated in DTC,indicating survivin was involved to angiogenesis and progress of DTC.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2010年第10期1149-1151,共3页
Cancer Research on Prevention and Treatment
基金
云南省教育厅科学基金资助项目(06Y133C)
