摘要
目的分析我院近4年抗肿瘤药物(西药)不良反应(ADR)监测情况,促进临床安全、合理用药。方法采用回顾性分析研究方法,对我院2006年1月至2009年6月上报的72例抗肿瘤药物ADR报告进行统计、分析与评价。结果 72份抗肿瘤药物ADR报告中,共涉及抗肿瘤药物11个品种;静脉滴注引发的ADR为51例,占71%;顺铂引发的ADR最多见,有35例,占49%;消化系统ADR最常见,占36%;重度ADR 10例,占14%,为速发型反应。发生ADR的患者中男女比例为1.67∶1。结论我院抗肿瘤药物使用中静脉滴注引发的ADR较多,应予以特别关注。必须定期监测与分析ADR情况。
AIM To investigate the adverse drug reactions（ADR） caused by antineoplastics in our hospital,so as to promoting safe and rational drug use.METHODS Seventy-two ADR reports collected between February 2006 and June 2009 in our hospital were analyzed retrospectively.RESULTS Eleven types of drugs were involved in 72 ADR cases.In the total ADR cases,51 ADR（71%） were caused by intravenous route of administration,35 ADR（49%） were caused by cisplatin.The digestive system lesion was primary（36%）.10 severe ADR（14%） was immediate allergic reaction.The ADR in male were more than that in female,and the proportion was 1.67 ∶ 1.CONCLUSION The ADR of antineoplastics caused by intravenous drop infusion is more in our hospital,which should be emphasized and give more attention.The ADR induced by antineoplastics should be monitored and reported regularly,in order to reduce or avoid the occurrence of ADR.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2010年第9期704-707,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
上海市医院药学科研基金项目-肿瘤药学专项(2008-YY-0213)
关键词
抗肿瘤药
药物不良反应
药物监测
安全
antineoplastic agents
adverse drug reactions
drug monitoring
safety
