摘要
目的:观察PCI对冠心病患者血IL-6、hs-CRP、ox-LDL的影响,探讨IL-6、hs-CRP、ox-LDL与冠脉病变程度的相关性。方法:对94例冠心病患者行冠状动脉造影(SCAG),按SCAG结果分为PCI组67例和对照组27例,两组均于术前及术后4小时取肘静脉血,测定血清hs-CRP、IL-6及ox-LDL水平。结果:与术前比较,PCI组术后血清hs-CRP水平显著增高(P<0.05),IL-6、ox-LDL水平差异无统计学意义(P>0.05);与对照组比较,PCI组术前、术后血清hs-CRP、IL-6、ox-LDL水平差异均有统计学意义(P<0.05)。多支及双支病变组术前和术后血清hs-CRP水平显著高于单支病变组(P<0.05);多支病变组术前和术后IL-6水平显著性高于双支和单支病变组(P<0.05);三组间ox-LDL水平差异无统计学意义(P>0.05)。弥漫病变组和长病变组血清hs-CRP、IL-6水平明显高于局限病变组,差异有统计学意义(P<0.05);血清ox-LDL水平各组间比较,差异无统计学意义(P>0.05)。结论:炎症因子与ox-LDL对CHD的诊断、危险性预测具有临床价值。CHD患者血清IL-6、hs-CRP水平与冠脉病变程度存在相关性。
Objective：To observe the effect of percutaneous coronary internvention（PCI） on the serum levels of hs-CRP,IL-6 and ox-LDL in patients with coronary heart disease（CHD） and to analyze the relationship between their levels and the severity of CHD.Methods：Selective coronary angiography was performed in 94 CHD patients.Angiographic images showed that CHD patients with one-vessel,two-vessel,and multi-vessel stenosis and showed long,diffuse,and local lesions.The patients were divided into PCI group（67 patients） and control group（27 patients） by different angiographic results.Blood samples were harvested in 4 hours after treatment and serum hs-CRP,IL-6 and ox-LDL levels were measured.Results：Compared to those before treatment,hs-CRP was significantly increased in the PCI group（P〈0.05）,while IL-6 and ox-LDL did not differ（P〉0.05）;compared to those in the control group,hs-CRP,IL-6,and ox-LDL were markedly different both before and after treatment（P〈0.05）.Both before and after treatment,CHD patients with two-and multi-vessel stenosis had higher hs-CRP level than those with one-vessel did（P〈0.05）;those with multi-vessel stenosis had higher IL-6 level than those with one-or two-vessel stenosis（P〈0.05）;no difference was noted in ox-LDL level among the 3 groups.CHD patients with diffuse and long lesions had increased hs-CRP and IL-6 as compared to those with local lesions（P〈0.05）;ox-LDL did not differ among the 3 groups（P〉0.05）.Conclusion：PCI may be effective to improve the levels of hs-CRP,IL-6 and ox-LDL and these factors are related to the severity of CHD.
出处
《浙江中西医结合杂志》
2010年第11期661-662,668,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
