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血府逐瘀汤对37例冠心病心绞痛患者细胞因子及氧自由基的影响 被引量:22

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摘要 目的:观察血府逐瘀汤治疗冠心病心绞痛的临床疗效及对细胞因子及氧自由基的影响。方法:对照组口服消心痛、肠溶阿司匹林等,治疗组在此基础上加服血府逐瘀汤,观察治疗前后外周血细胞因子及氧自由基的变化。结果:治疗组、对照组心绞痛疗效总有效率分别为89.19%,74.29%;心电图疗效总有效率分别为72.97%,45.71%。组间对比,有统计学意义(P〈0.05)。治疗组治疗后白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)、丙二醛(MDA)含量较治疗前降低,超氧化物歧化酶(SOD)活性升高,差异有统计学意义(P〈0.01)。对照组治疗前、后IL-6、TNF-α、SOD、MDA含量变化无统计学意义(P〉0.05)。两组治疗后IL-6、TNF-α、SOD、MDA含量对比,差异有统计学意义(P〈0.05~0.01)。结论:血府逐瘀汤对冠心病心绞痛具有较好的治疗作用,且能降低IL-6、TNF-α、MDA含量,升高SOD。认为血府逐瘀汤对冠心病心绞痛患者的治疗作用,在一定程度上与其抑制炎症细胞因子分泌、促进机体氧自由基清除有关。
作者 容兆宇
出处 《中医研究》 2006年第7期26-28,共3页 Traditional Chinese Medicinal Research
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