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Wnt诱导分泌蛋白-1与器官纤维化 被引量：4

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摘要 Wnt信号通路参与调节机体发育诸多过程,Wnt信号通路异常激活可以导致肿瘤、纤维增生等疾病过程的发生。Wnt诱导分泌蛋白-1(WISP-1)是Wnt信号通路活化后的下游靶基因之一,最近研究表明WISP-1与肺、心脏、肝等脏器纤维化相关,此文就WISP-1与器官纤维化的研究进展作一综述。
作者 简易成 熊伍军
机构地区 同济大学附属东方医院消化内科
出处 《国际消化病杂志》 CAS 2010年第5期297-299,共3页 International Journal of Digestive Diseases
基金 上海市浦东新区科技发展基金创新资金(PKJ2009-Y16)
关键词 WNT信号通路 Wnt诱导分泌蛋白-1 纤维化
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献16

  • 1MacDonald BT,Tamai K,He X.Wnt/beta-catenin signaling:components,mechanisms,and diseases.Dev Cell,2009.17:9-26.
  • 2Clevers H.Wnt/beta-catenin signaling in development and disease.Cell,2006,127:469-480.
  • 3Bowley E,O'Gorman DB,Gan BS.Beta-catenin signaling in fibroproliferative disease.J Surg Res,2007,138:141-150.
  • 4Hashimoto Y,Shindo-Okada N,Tani M,et al.Identification of genes differentially expressed in association with metastatic potential of K-1735 murine melanoma by messenger RNA differential display.Cancer Res,1996,56:5266-5271.
  • 5Pennica D,Swanson TA,Welsh JW,et al.WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.Proc Natl Acad Sci U S A,1998,95:14717-14722.
  • 6Leask A,Parapuram SK,Shi-Wen X,et al.Connective tissue growth factor(CTGF,CCN2)gene regulation:a potent clinical bio-marker of fibroproliferative disease? J Cell Commun Signal,2009,3:89-94.
  • 7Desnoyers L,Arnott D,Pennica D.WISP-1 binds to decorin and biglycan.J Biol Chem,2001,276:47599-47607.
  • 8Konigshoff M,Wilhelm J,Jahn A,et al.Wnt-inducible protein(WISP-1)is a key regulator of alveolar epithelial cell hyperplasia in pulmonary fibrosis.Eur Respir Rev,2006,15:180-181.
  • 9Lewis CC,Yang JY,Huang X,et al.Disease-specific gene expression profiling in multiple models of lung disease.Am J Respir Crit Care Med,2008,177:376-387.
  • 10Selman M,Pardo A,Barrera L,et al.Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis.Am J Respir Crit Care Med,2006,173:188-198.

二级参考文献11

  • 1Jiang F, Parsons CJ, Stefanovic B. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol, 2006, 45: 401-409.
  • 2Cheng JH, She H, Han YP, et al. Wnt antagonism inhibits hepatic stellate ceil activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol, 2008, 294: G39-G49.
  • 3Mattern J, Koomagi R, Volm M. Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumor cell proliferation in human epidermoid lung carcinoma. Br J Cancer, 1996, 73:931-934.
  • 4Bejsovec A. Wnt pathway activation: new relations and locations. Cell, 2005, 120: 11-14.
  • 5Veeman MT, Axelrod JD, Moon RT. A second canon. Functions and mechanisms of beta-catenin independent Wnt signaling. Dev Cell, 2003,5:367-377.
  • 6Zeng G, Awan F, Otruba W, et al. Wnt'er in liver:expression of Wnt and frizzled genes in mouse. Hepatology, 2007,45: 195-204.
  • 7Shackel NA, McGuinness PH, Abbott CA, et al. Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis:cDNA array analysis of intrahepatic differential gene expression. Gut, 2001,49, 565-576.
  • 8Colston JT, de la Rosa SD, Koehler M, et al. Wnt-induced secreted protein-1 is a prohypertrophic and profihrotic growth factor. Am J Physiol Heart Circ Physiol, 2007, 293: H1839-H846.
  • 9Fukushima M, Nakamuta M, Kohjima M, et al. Fasudil hydrochloride hydrate, a Rho kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int, 2005, 25: 829-838.
  • 10Svegliati-Baroni G, Ridolfi F, Caraclonna Z,et al. Regulation of ERK/JNK/pTOS6K in two rat models of liver injury and fibrosis. J Hepatol, 2003,39:528-537.

共引文献5

同被引文献52

  • 1于晓敏,王辰,王军.Wnt信号通路的生物学效应及其与肺部疾病的关系[J].首都医科大学学报,2009,30(2):182-184. 被引量：16
  • 2李杨,宋良文,王德文,彭瑞云,高亚兵,马俊杰.γ射线对肺成纤维细胞中转录因子SP1,AP1和Smad3-Smad4活性的影响及意义[J].中华放射医学与防护杂志,2005,25(4):329-332. 被引量：3
  • 3刘学良,王世山,张厚才.放射性肺损伤的影像学诊断(附70例分析)[J].中国中西医结合影像学杂志,2006,4(6):433-435. 被引量：9
  • 4刘英,李杨,彭瑞云,王水明,高亚兵,马俊杰,宋良文.γ射线对C57BL/6J和C3H/HeN小鼠肺成纤维细胞生物学行为影响的比较研究[J].细胞与分子免疫学杂志,2007,23(4):295-298. 被引量：4
  • 5MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases[J]. Dev Cell, 2009, 17(1): 9-26.
  • 6Konigshoff M, Wilhelm J, Jahn A, et al. Wnt-inducible protein (WISP-1) is a key regulator of alveolar epithelial cell hyperplasia in pulmonary fibrosis[J], Eur Respir Rev, 2006, 15(101): 180-181.
  • 7Selman M, Pardo A, Barrera L, et al. Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis[J]. Am J Respir Crit Care Med, 2006, 173(2): 188-198.
  • 8Konigshoff M, Kramer M, Balsara N, et al. WNTl-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis[J]. J Clin Invest, 2009, 119(4): 772-787.
  • 9Colston JT, de la Rosa SD, Koehler M, et al. Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor[J]. Am J Physiol Heart Circ Physiol, 2007, 293(3): H1839-1846.
  • 10Venkatachalam K, Venkatesan B, Valente A J, et al. WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death[J]. J Biol Chem, 2009, 284(21): 14414-14427.

引证文献4

二级引证文献2

国际消化病杂志
2010年 第5期

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