摘要
目的研究葆菁康(补肾益气活血方)对大鼠血脂与血栓的影响。方法用自然衰老和高脂血症模型大鼠,观察葆菁康对血中总胆固醇、游离胆固醇、甘油三酯、低密度脂蛋白及高密度脂蛋白的影响;用ADP诱导法测定血小板聚集率;用放免法测定6-酮-前列腺素F1α和血栓素-B2。结果葆菁康可降低自然衰老和高脂血症大鼠血脂水平及降低血栓素-B2/6-酮-前列腺素F1α比值;葆菁康可降低高脂血症大鼠血小板聚集率和血栓形成,均有统计学意义(P<0.05,0.01)。结论葆菁康能降低自然衰老和高脂血症大鼠血脂水平及减少血栓形成。
Objective To study the effects of BaoJingKang on blood lip- id and thrombosis formation. Methods The effects of BaoJingKang were measured on the total cholesterol （ TC ） , free cholesterol （ FC ） , triglyceride （TC）, low density lipoprotein （ LDL - C） and high density lipopro- tein （HDL - C ） with the nature aging and hyperlipidemia rats. The effects of BaoJingKang were measured on the platelet aggregation by ADP-induced method, on 6 - keto - PGF1α and thromboxane B2 （ TXB2 ） by radio - immunity method, respectively. Results BaoJing- Kang can decrease the level of blood lipid and the ratio of TXB2/6 - keto- PGF1α of the nature aging and hyperlipidemia rats. BaoJingKang decrease the platelet aggregation, decrease thrombosis formation in hyper- lipidemia rats. Conclusion BaoJingKang can decrease the level in blood lipid and decreased the thrombosis formation in the nature aging and hyperlipidemia rats.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2010年第10期764-767,共4页
The Chinese Journal of Clinical Pharmacology
