摘要
目的:观察苯巴比妥预防早产儿脑室内出血(intraventricular hemorrhage,IVH)的疗效以及安全性。方法:将胎龄≤35周、日龄<6 h的86例早产儿以单、双月收住院分为观察组49例和对照组37例,2组常规处理相同;观察组入院后即予苯巴比妥负荷量应用(20 mg/kg分2次缓慢静脉注射),24 h后给维持量应用(5 mg.kg-1.d-1分2次间隔12 h缓慢静脉注射),疗程5天。比较2组IVH和重度IVH以及呼吸暂停和反应低下的发生率。结果:观察组IVH的发生率为20.4%,较对照组37.8%降低(P<0.05)。观察组重度IVH的发生率为4.1%,对照组为8.1%;观察组呼吸暂停的发生率为34.7%,对照组为40.5%;观察组反应低下的发生率为24.5%,对照组为21.6%,差异均无统计学意义(P>0.05)。结论:苯巴比妥能有效预防早产儿IVH的发生,无严重不良反应,其应用是安全的。
Objective：To investigate the therapeutic efficacy and safety of phenobarbital in preventing premature newborns from intraventricular hemorrhage（IVH）.Methods：Eighty-six premature newborns（≤35 weeks gestation and 6 hours post partum）were divided into treatment group（hospitalized in the singular month,n=49）and control group（hospitalized in the even month,n=37）.Both groups received the same routine therapy.The patients in the treatment group were administered phenobarbital（20 mg/kg twice via intravenous drip）immediately after admission,followed by a course of 5 days′ maintenance dosage（5 mg/kg intravenous drip with 12 hours interval）after 24 hours.The incidences of IVH,severe IVH,respiratory arrest and low response were compared between the two groups.Results：The phenobarbital treatment group had a significantly lower incidence of IVH（20.4%）than the control group（37.8%）（P0.05）.However,there was no difference in the incidence of severe IVH,respiratory arrest or low response between the treatment group（4.1%,34.7% and 24.5%,respectively）and the control group（8.1%,40.5% and 21.6%,respectively）.Conclusions：Phenobarbital can effectively and safely prevent the incidence of IVH in premature newborns,and leaves no significant side effects.
出处
《蚌埠医学院学报》
CAS
2010年第10期1030-1032,共3页
Journal of Bengbu Medical College
关键词
婴儿
早产
疾病
颅内出血
苯巴比妥
预防
infant
premature
diseases
intraventricular hemorrhage
phenobarbital
prevention
