摘要
目的 探讨极低出生体重儿脑室内出血 (IVH)的临床特点和危险因素。方法 对新生儿重症监护病房 48例并发IVH的极低出生体重儿与同期住院治疗、曾经头颅B超检查的 77例极低出生体重儿进行回顾性对照分析。比较两组患者的临床特点 ,采用非条件Logistic回归进行多因素分析并计算OR值及OR的95 %可信限 ( 95 %CI)。结果 极低出生体重儿IVH的发病率为 3 8 4%。多因素非条件Logistic回归分析显示 :围产期窒息 (OR =6 3 79,95 %CI=1 192～ 3 4 14 4)、机械通气时间 (OR =8 3 74,95 %CI=2 5 61～ 2 7 3 88)和苯巴比妥治疗 (OR =0 0 81,95 %CI=0 0 2 3～ 0 2 68)为极低出生体重IVH的独立相关因素。结论 IVH在早产儿中发生率高 ,围产期窒息、机械通气时间和苯巴比妥治疗与极低出生体重儿IVH的发生有密切关系。
Objective To identify the clinical characteristics and risk factors of intraventricular hemorrhage (IVH) in the very low birth weight infants. Methods A case-control study was conducted in 125 very low birth weight (VLBW) infants. The case group was those neonates with IVH, and the control group was those without IVH. Non-conditional logistic regression analysis was performed to determine the risk factors for IVH. The odds ratios (OR) and their 95% confidence intervals (95%CI) were estimated. Results The incidence rate of intraventricular hemorrhage was 38.4% in VLBW infants. By non-conditional logistic regression analysis, perinatal asphyxia (OR=6.379, 95% CI=1.192～34.144), duration of mechanical ventilation (OR=8.374, 95% CI=2.561～27.388), treatment with phenobarbital (OR=0.081; 95% CI=0.023～0.268) were significantly associated with IVH independently. Conclusions Perinatal asphyxia, duration of mechanical ventilation and treatment with phenobarbital are significantly correlated with the occurrence of IVH in VLBW infants.
出处
《浙江预防医学》
2004年第8期9-10,12,共3页
Zhejiang Journal of Preventive Medicine
