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脂肪干细胞定向分化的影响因素 被引量：11

Directional Differentiation of Adipose-Derived Stem Cell
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摘要 脂肪干细胞是一类由脂肪组织分离出来的间充质干细胞,具有自我更新和多向分化潜能,可长期自我更新并在特定的条件下分化形成多种终末细胞。本文总结近年来关于脂肪干细胞定向分化的研究成果、介绍脂肪干细胞的分离培养技术、影响脂肪干细胞成脂成骨定向分化能力的主要因素,以及在各种终末分化细胞之间"转分化"的作用条件,从而为寻找治疗肥胖的新靶点以及骨组织工程学提供新思路。 Adipose-derived stem cells（ADSCs） are mesenchymal stem cells（MSCs） derived from adipose tissue,which have the ability to self-renew and differentiate into many types of tissues.Here we summarize the recent advances in the research of ADSCs,introduce the methods of ADSCs isolation and culture,and discusse the factors regulating the adipo-differentiation and osteo-differentiation of ADSCs.The present review will yield novel insight relevant to the therapeutic intervention of obesity and osteo-tissue engineering.
作者 相新新 赵晶 李茵 张炜真
机构地区 北京大学医学部基础医学院生理学与病理生理学系
出处 《生理科学进展》 CAS CSCD 北大核心 2010年第5期341-346,共6页 Progress in Physiological Sciences
基金 国家自然科学基金(30971085 30871194)资助课题
关键词 脂肪干细胞 分化 adipose-derived stem cells differentiation
分类号 Q254 [生物学—细胞生物学]
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参考文献20

  • 1Katz AJ,Tholpady A,Tholpady SS,et al.Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells.Stem cells,2005,23:412-423.
  • 2Rodeheffer MS,Birsoy K,Friedman JM.Identification of white adipocyte progenitor cells in vivo.Cell,2008,135:240-249.
  • 3Zhu M,Kohan E,Bradley J,et al.The effect of age on osteogenic,adipogenic and proliferative potential of female adipose-derived stem cells.J Tissue Eng Regen Med,2009,3:290-301.
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  • 6Kakudo N,Shimotsuma A,Kusumoto K.Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells.Bioche Biophys Res Commun,2007,359:239-244.
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  • 9黎洪棉,柳大烈,余元龙,吴涛.自体PRP促进人脂肪来源干细胞成骨分化的体外实验研究[J].中国修复重建外科杂志,2009,23(6):732-736. 被引量：10
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二级参考文献22

  • 1Zuk PA,Zhu M,Mizuno H,et al,Multilineage cells from human adipose tissue:implications for cell-based therapies.Tissue Eng,2001,7(2):221-228.
  • 2Dicker A,Le Blanc K,Astrom G,et al.Functional studies of mesenchymal stem cells derived from adult human adipose tissue.Exp Cell Res,2005,308(2):283-290.
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  • 4De Ugarte DA,Morizono K,Elbarbary A,et al.Comparison of multilineage cells from human adipose tissue and bone marrow.Cells Tissues Organs,2003,174(3):101-109.
  • 5De Girolamo L,Sartori MF,Arrigoni E,et al.Human adipose-derived stem cells as future tools in tissue regeneration:osteogenic differentiation and cell-scaffold interaction.Int J Artif Organs,2008,31(6):467-479.
  • 6Cao Y,Sun Z,Liao L,et al.Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo.Biochem Biophys Res Commun,2005,332(2):370-379.
  • 7Vermette M,Trottier V,Menard V,et al.Production of a new tissueengineered adipose substitute from human adipose-derived stromal cells.Biomaterials,2007,28(18):2850-2860.
  • 8Kingham PJ,Kalbermatten DF,Mahay D,et al.Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro.Exp Neurol,2007,207(2):267-274.
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  • 10Aghaloo TL,Moy PK,Freymiller EG.Investigation of platelet-rich plasma in rabbit cranial defects:a pilot study.J Oral Maxillofac Surg,2002,60(10):1176-1181.

共引文献9

同被引文献253

引证文献11

二级引证文献46

生理科学进展
2010年 第5期

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