摘要
目的探讨凋亡抑制因子Bcl-xl在乳腺癌中的表达及与临床病理特征、雌孕激素受体表达的关系。方法用S-P免疫组织化学技术检测39例浸润性乳腺癌组织、35例癌周组织及30例正常、30例增生乳腺组织中凋亡抑制因子Bcl-xl的表达。结果与癌周组织、增生及正常的乳腺组织相比,乳腺癌组织中Bcl-xl呈过表达(P<0.05);乳腺癌组织中Bcl-xl表达随临床分期的升高而升高(P<0.05),随组织分级的增高而升高(P<0.05);乳腺癌组织中Bcl-xl表达和雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)表达呈负相关(P<0.05);同时也与乳腺癌患者有无腋窝淋巴结转移有关,其在有淋巴结转移组高于无淋巴结转移组(P<0.05)。结论乳腺癌组织中Bcl-xl表达与肿瘤分期,细胞学分级,有无腋窝淋巴结转移,ER、PR表达有相关性,在乳腺癌的发生发展过程中有不可忽视的作用。
Objective To detect apoptosis-suppressor gene Bcl-xl expression in breast cancer tissues,and to discuss its correlation with clinical pathology characteristics and estrogen receptor （ER） and progesterone receptor （PR） expressions.Methods Bcl-xl,ER and PR expressions were determined in 39 cases of breast cancer tissues,39 cases of breast tissues adjacent to carcinoma,30 cases of hyperplastic breast tissues and 30 cases of normal breast tissues by the S-P method.Results Compared with normal breast tissues adjacent to carcinoma and hyperplasia and normal breast tissues,the posi-tive rate of Bcl-xl in breast cancer tissues was significantly higher than the former （P0.05） .There were relations be-tween the clinical stage and expression of Bcl-xl,the higher the stage,the more the expression （P0.05） .The same sit-uation was on classification of tumor cells.There were some negative correlations among expressions of ER,PR and Bcl-xl （P0.05） ,also there was a relationship with axillary lymph node metastasis （P0.05） .Conclusion The apoptosis suppressor gene Bcl-xl in breast cancer tissues had significant relation to clinical stage,classification of tumor cells,axilla-ry lymph node metastasis or not and expressions of ER and PR,it may play an important epigenetics role in breast cancer.
出处
《山东大学学报（医学版）》
CAS
北大核心
2010年第9期104-106,共3页
Journal of Shandong University:Health Sciences
