摘要
目的 探讨帕金森病（PD）患者基于事件的前瞻性记忆（EBPM）和基于时间的前瞻性记忆（TBPM）损害特点.方法 对87例PD患者和85名健康对照者进行EBPM和TBPM检查,并分为老年组和非老年组进行比较.结果 （1）老年和非老年PD组EBPM检查成绩[分别为（2.5±0.4）分和（3.9±2.4）分]均明显低于同龄对照组[分别为（5.8±1.3）分和（6.3±1.5）分],差异有统计学意义（均P＜0.01）;老年和非老年PD组TBPM成绩[分别为（3.6±0.5）分和（4.8±0.9）分]与同龄对照组[分别为（3.8±0.8）分和（4.9±0.9）分]比较,差异无统计学意义（均P＞0.05）.（2）PD患者Hoehn-Yahr分级与EBPM得分呈正相关（P＜0.05）,而与TBPM得分不相关（P＞0.05）.结论 PD患者EBPM存在损害,而TBPM相对正常.EBPM损害与PD患者疾病严重程度有关.
Objective To explore the characteristics of event-based prospective memory （EBPM） and time-based prospective memory （TBPM） impairments in patients with Parkinson＇s disease （PD）. Methods EBPM and TBPM were examined in 87 PD patients and 85 healthy controls. And both of them were divided into two groups： aged group （≥60 years old） and non-aged group （＜60 years old）. Results （1） The scores of EBPM were significantly lower in aged PD patients and non-aged PD patients than in age-matched control groups [（2. 5±0. 4） vs. （5.8± 1.3）,（3.9±2.4） vs. （6.3±1.5）, both P＜0. 01]. There were no significant differences in the scores of EBPM between aged PD patients or non-aged PD patients and their age-matched control groups [（3.6±0.5） vs. （3.8±0.8）, （4.8±0.9） vs. （4.9±0.9）, both P＞0.05]. （2）The Hoehn-Yahr grade in PD patients was significantly correlated with scores of EBPM, but not with scores of TBPM.Conclusions The patients with PD have an impairment in EBPM, but not in TBPM. The impairment of EBPM may be related to the disease severity of PD.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2010年第10期793-795,共3页
Chinese Journal of Geriatrics
基金
河南省医学科技攻关项目（200803105）
关键词
帕金森病
记忆障碍
神经心理学测验
Parkinson disease
Memory disorders
Neuropsychological tests
