摘要
目的了解缺血性脑白质病变（WMIL）患者前瞻性记忆改变的情况，初步探讨WMIL患者基于事件的前瞻性记忆（EBPM）和基于时间的前瞻性记忆（TBPM）损害的特点。方法建立前瞻性记忆的神经心理学测验方法，测试年龄、受教育程度等相匹配的30例对照者和30例WMIL患者的EBPM和TBPM。结果WMIL患者的TBPM成绩（分）较对照组明显损害（2．2±1．4、5．0±1．1，t=-8．483，P〈0．01），而EBPM成绩（分）较对照组差异无统计学意义（4．3±1．6、4．0±1．5，t=0．667，P〉0．05）；且TBPM成绩与白质病变严重程度、白质病变对脑内胆碱能通路的损伤程度均呈负相关（r=-0．387、-0．416，均P〈0．05）。结论WMIL患者存在前瞻性记忆的损害，表现为TBPM损害突出，且病变越严重TBPM损害越明显，而EBPM却相对正常；WMIL患者TBPM损害程度与其对脑内胆碱能通路的损伤程度相关，提示胆碱能通路损害可能参与TBPM的发病机制。
Objective To study impairment of the prospective memory including event-based prospective memory （EBPM） and time-based prospective memory （TBPM） in patients with white matter ischemic lesion （WMIL）. Methods Set a neuropsychological battery to measure EBPM and TBPM in 30 educationand age-matched patients with WMIL and normally aging adults. Results Compared with the healthy controls, WMIL patients demonstrated a selective impairment in their ability to perform TBPM （2. 2 ± 1.4,5.0 ± 1.1 ; t = - 8.483, P 〈0. 01 ）, but no group difference in performance on EBPM tasks （4.3±1.6,4.0 ± 1.5; t =0.667,P〉0.05）. In addition, both the severity of WMIL and extent of impairment in cholinergic pathways by WMIL were negatively correlated to TBPM （ r = - 0. 387, - 0. 416 ; both P 〈 0. 05 ）. Conclusions WMIL patients demonstrated a selective impairment in TBPM, and the more severe WMIL was, the poorer TBPM impaired. EBPM remains not impaired. The results suggest that TBPM and EBPM may have different neuromechanisms and indicates cholinergic pathways may be the neuromechanism of TBPM.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2010年第3期178-181,共4页
Chinese Journal of Neurology
基金
国家十一五科技支撑计划资助项目（2006BA102801）
国家“973”项目子课题资助项目（2005CB522800）
国家自然科学基金资助项目（30870766,30670706）
