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神经毒性物质在多发性硬化发病及治疗中的意义 被引量：2

Neurotoxic substances in the pathogenesis and treatment of multiple sclerosis
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摘要 多发性硬化（multiple sclerosis，MS）是一种中枢神经系统炎症性脱髓鞘性疾病，其主要病理特点有炎症侵润、髓鞘脱失及轴索变性、神经元及少突胶质细胞丧失，发病机制目前尚不十分明确。越来越多学者认为神经毒性机制参与了MS的发病，为MS治疗研究提供了新思路。神经毒性物质，是指对胶质细胞、神经元、轴索具有直接毒性作用，能导致其坏死、凋亡的物质，主要有兴奋性氨基酸、氧化物、凋亡相关蛋白、钙离子、钙蛋白酶等。本文就MS的神经毒性物质的研究进展做一综述。
作者 舒崖清 胡学强
机构地区 中山大学附属第三医院神经科
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2010年第10期1075-1077,共3页 Chinese Journal of Neuromedicine
关键词 多发性硬化 神经毒性 治疗 Multiple sclerosis Neurotoxicity Therapy
分类号 R686 [医药卫生—骨科学]
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参考文献24

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同被引文献27

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引证文献2

中华神经医学杂志
2010年 第10期

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