摘要
越来越多的证据显示,高同型半胱氨酸血症不仅是脑血管病的高危因素,而且还与Alzheimer病、Parkinson病、痴呆、认知障碍、抑郁症和精神分裂症等多种神经变性疾病和精神疾病密切相关。同型半胱氨酸的神经毒性机制尚不完全清楚,可能包括通过激活细胞外信号调节激酶、过度激活谷氨酸受体、参与氧化应激反应、影响甲基化过程和损伤DNA等。
Growing evidence indicates that hyperhomocysteinemia is not only a high risk factor for cerebrovascular diseases, but also closely correlated with neurodegenerative diseases and mental diseases, such as Alzheimer＇s disease, Parkinson＇s disease, dementia, cognitive impairment, depression and schizophrenia, The mechanisms of homocysteine neurotoxicity remains unclear, and it may include activating extracellular signal-regulated kinases, excessively activating glutamate receptors, participating in oxidative stress response, affecting methylation process and damaging DNA.
出处
《国际脑血管病杂志》
2007年第12期939-942,共4页
International Journal of Cerebrovascular Diseases
