摘要
目的探讨人乳头瘤病毒(HPV)多重感染与宫颈病变的关系。方法对2008年1月至2010年1月期间在桂林医学院附属医院妇科门诊就诊的774位女性的宫颈细胞标本进行HPV基因型分型检测,比较不同宫颈病变类型组HPV多重感染的比例。结果本组资料中多重感染的比例为37.77%,其中以二重感染常见(85/139,61.15%),偶有六重感染(2/139,1.44%),最常见类型为HPV 16、58及HPV 16、18二重感染。HPV多重感染检出率在宫颈鳞癌组、宫颈上皮内瘤样病变(CIN)Ⅲ组、CINⅡ组、CINⅠ组、炎症组和正常组分别为40.00%、61.11%、50.71%、39.32%、30.56%和12.28%。除宫颈鳞癌组,HPV多重感染的比例随宫颈病变级别增加而增加,各组与正常组相比,差异均有统计学意义(均P<0.05)。结论 HPV多重感染与宫颈病变的发生有关。
Objective To investigate the role of multiple human papilloma virus（HPV）infections in cervical dysplasia.Methods The cervical samples of 774 women who visited Affiliated Hospital of Guilin Medical College from January 2008 to January 2010 were randomly selected for 23 HPV subtypes,and the multiple infection rate in different cervical lesions was calculated.Results The total multiple infection rate was 37.77%.Among them,double infection was common（85/139,61.15%）,sextuple infection was rarely seen（2/139,1.44%）.The most common types were HPV 16/58 and HPV 16/18 double infections.The detection rate of multiple HPV infections was 40.00% in cervical cancer group,61.11% in CIN Ⅲ group,50.71% in CIN Ⅱ group,39.32% in CIN Ⅰ group,30.56% in inflammation group,and 12.28% in normal group respectively.The multiple infection rate was increased with the severity of cervical dysplasia（except for cervical cancer）,and significantly higher than in normal group（all P〈0.05）.Conclusion Multiple HPV infection is associated with the development of cervical neoplasia.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2010年第5期705-707,715,共4页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金
广西壮族自治区自然科学基金资助项目(No.桂科自0728235)
关键词
人乳头瘤病毒
多重感染
宫颈病变
human papilloma virus
multiple infection
cervical lesion
