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HPV感染与子宫颈癌发病关系的探讨 被引量:18

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摘要 目的 :探讨 HPV感染与宫颈癌发病关系。方法 :采用 PCR方法对 32例宫颈癌、4 8例宫颈糜烂、2 1例正常宫颈的宫颈分泌物进行 HPV检测。结果 :1宫颈癌患者 HPV的检出率明显高于宫颈糜烂、正常宫颈者 (P <0 .0 5 ) ;2初婚年龄 <1 8岁者 ,在宫颈癌、宫颈糜烂及正常宫颈中分泌物 HPV的检出率高于初婚年龄≥ 1 8岁者 (P <0 .0 5 ) ;3<4 0岁者宫颈糜烂及正常宫颈中分泌物 HPV的检出率高于≥ 4 0岁者 (P <0 .0 5 ) ,但在宫颈癌患者中差异无统计学意义 ;4在正常宫颈、宫颈糜烂及宫颈癌患者宫颈分泌物中 ,妊娠次数 >1次者 HPV的检出率与妊娠次数≤ 1次者相比较差异无统计学意义。结论 :HPV感染是癌前病变及癌变的主要原因 ,对 HPV感染患者应密切观察。
出处 《广西医科大学学报》 CAS 2004年第2期222-224,共3页 Journal of Guangxi Medical University
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  • 1Bosch FX,Lorincz A, Munoz N, et al. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol, 2002,55(4):244-265.
  • 2Harper DM, Noll WW, Belloni DR, et al. Randomized clinical trial of PCR-determined human papillomavirus detection methods: self-sampling versus clinician-directed-biologic concordance and women's preferences. Am J Obstet Gynecol,2002,186(3):365-373.
  • 3Denise Zielinski G,Snijders PJ,Rozendaal L,et al.High-risk HPV testing in women with borderline and mild dyskaryosis: long-term follow-up data and clinical relevance. J Pathol, 2001,195(3):300-306.
  • 4Deacon JM, Evans CD,Yule R, et al. Sexual behaviour and smoking as determinants of cervical HPV infection and of CIN3 among those infected: a case-control study nested within the Manchester cohort.Br J Cancer,2000,88(11):1 565-1 572.
  • 5Ho GY,Bierman R,Beardsley L,et al.Nature history of cervicovaginal papillomavirus infection in young women.N Engl J Med,1998,338(7):423-428.
  • 6Sellors JW,Mahony JB,Kaczorowski J,et al.Prevalence and predictors of human papillomavirus infection in women in Ontario,Canada.Survey of HPV in Onfario Women (SHOW) Group.CMAJ,2000,163(5):503-508.
  • 7Kjellberg L, Hallmans G, Ahren AM, et al. Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection. Br J Cancer,2000 ,82(7):1 332-1 338.
  • 8Herrero R, Hildesheim A, Bratti C, et al. Population-based study of human papillomavirus infection and cervical neoplasia in rural Costa Rica. J Natl Cancer Inst,2000, 92(6):464-474.
  • 9Josefsson AM,Magnusson PK,Ylitalo N,et al.Viral load of human papiloma virus 16 as a determinant for development of cervical carcinoma in situ: a nested case-control study.Lancet,2000,355(9 222):2 189-2 193.
  • 10Mandelblatt JS, Lawrence WF, Gaffikin L, et al. Costs and benefits of different strategies to screen for cervical cancer in less-developed countries. J Natl Cancer Inst, 2002, 94(19):1 469-1 483.

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