摘要
目的揭示口腔颌面部恶性肿瘤与Ｅｐｓｔｅｉｎ－Ｂａｒ（ＥＢ）病毒感染的关系。方法采用聚合酶链（ＰＣＲ）反应技术，对１８例口腔颌面部恶性肿瘤患者的组织标本及其唾液内的ＥＢ病毒ＤＮＡ（ＥＢＶ－ＤＮＡ）存在情况进行检测，并以正常人作为对照。结果肿瘤组织标本中有３例唾液腺恶性肿瘤分别检出了ＥＢＶ－ＤＮＡ片段，这３例的唾液脱落上皮细胞中也扩增出ＥＢ病毒的基因片段；而正常人和其它肿瘤组织及唾液检测结果为阴性。结论唾液腺肿瘤可能与ＥＢ病毒的感染存在着一定的关系。
Objective To indicate the relationship between infection of
the EpsteinBarr virus and malignant tumors of oral and maxillofacial regions. Methods The
EpsteinBarr virus DNA was measured in tissues and saliva of 18 patients with malignant
tumors of oral and maxillofacial regions by polymerase chain reaction (PCR). Results It showed
that DNAs of EB virus fragment were amplified in tissues and saliva of 3 patients with salivary
carcinoma,but negative in controls and squamous cell carcinomas and sarcomas. Conclusion It
indicated that there was association between EpsteinBarr virus and salivary carcinoma.
出处
《上海口腔医学》
CAS
CSCD
1999年第2期78-79,共2页
Shanghai Journal of Stomatology
关键词
EB病毒
聚合酶链反应
口腔肿瘤
psteinBarr virus(EB)polymerase chain reaction(PCR)oral neoplasm
