摘要
在大鼠肝脏缺血再灌注模型基础上建立稳定的缺血预处理模型，观察其保护作用，结果发现预处理与缺血再灌注组相比血清肝酶（ＡＬＴ、ＡＳＴ），透明质酸水平及肝组织局部ＭＤＡ含量均低，而组织ＡＴＰ含量及能荷值均高，形态学损伤改变轻；同时发现预处理组组织腺苷含量明显高于缺血再灌注组。实验表明缺血预处理能有效减轻肝脏的缺血再灌注损伤，腺苷分子参与了这一保护机制。
Using ischemic preconditioning model and hepatic ischemia-reperfusion model in rats,this study investigated the protective effect of ischemic preconditioning.The results showed:(1)The serum ALT,AST and HA in IP groups were lower than those in I/R group(P<0.05);(2)MDA content in liver tissue was lower but ATP content and EC were higher in IP group than those in I/R group(P<0.05);(3)Histological findings showed less injury in IP groups;(4) Live tissue adenosine content was high in IP groups.It was suggested that IP could reduced the hepatic injury caused by the ischemia-reperfusion.Adenosine played an important role in this protection mechanism.
出处
《肝胆外科杂志》
1999年第3期222-224,共3页
Journal of Hepatobiliary Surgery
关键词
缺血预处理
再灌注损伤
肝
Ischemic preconditioningReperfusion injuryLiver
