摘要
目的建立CPB实验动物模型,加强围手术期麻醉管理,探索肺功能保护方法 ,以减少术后并发症的产生。方法 20只实验犬全部用于建立实验动物模型。丙泊酚复合麻醉后,开胸;全血肝素化后,连接体外循环管道开始体外循环,微量泵入丙泊酚50～150μg/(kg·min)维持麻醉;监测麻醉诱导前(T0)、气管插管即刻(T1)、CPB前即刻(T2)、降温至32.0℃(T3)、阻断主动脉前即刻(T4)、阻断主动脉后2min(T5)、开始复温即刻(T6)、停CPB即刻(T7)及停CPB后15min(T8)9个时间结点的鼻咽温度、平均动脉压(mean arterial pressure,MAP)及心率(heart rate,HR)。结果体外循环期间各时点鼻咽温度均低于T0及T2(P<0.05);T1、T2及体外循环期间各时点的MAP明显低于T0(P<0.05),体外循环期间各时点的MAP低于T2(P<0.05);T4的HR明显低于T0及T2(P<0.05)。体外循环期间各时点MAP比较无统计学意义(P>0.05)。结论犬体外循环模型建立的成败与手术技术和麻醉管理密切相关。
Objective To explore the method oflung’s function protecting and to reduce the postoperative complications by enhancing the anaesthetizing management of the operation period after modeling dogs＇ CPB. Methods 20 dogs were used on modeling. After the heparinization of the whole blood,the cardiopulmonary bypass began with pumping propofol at 50 ～ 150 μg/（kg·min）. The nasopharyngeal temperature,MAP and HR at different moments were monitored at the moment of anesthesia induction （T0）,the moment of tracheal intubation （T1）,the moment right on CPB（T2）,the moment of hypothermy at 32. 0℃（T3）,the moment of blocking the arteriae aorta（T4）,2 min after aorta blocking（T5）, the moment of rewarming （T6）,the moment of stopping CPB（T7） and 15 min after stopping CPB（T8）. Results Through double factors analysis of variance,the nasopharyngeal temperatures during the CPB were markedly lower than T0 and T2 （P〈0. 05）. The MAP at T0 was visibly higher than the others （P〈0. 05）. The MAP during the CPB was higher than the one at T2（P〈0. 05）. The HR at T4 was significantly lower than the ones at T0 and T2 （P〈0. 05）. The MAP during CPB was not statistically significant （P〈0. 05）. Conclusions The key on modeling dogs＇ CPB was the surgical technical and anaesthesia management.
出处
《中国比较医学杂志》
CAS
2010年第10期44-47,共4页
Chinese Journal of Comparative Medicine
关键词
体外循环
模型
动物
麻醉
丙泊酚
犬
Cardiopulmonary bypass （CPB）
Model
animal
Anaesthetizing
Propofol
Dog
