摘要
目的探讨密钙息合并介入治疗对骨转移癌的临床疗效。方法对４２例骨转移癌患者采用密钙息针剂１００ＩＵ肌注，每日１次，连用７ｄ为１疗程。同时对全组病人采用经皮骨转移病灶供血动脉插管化疗药物灌注，每２０ｄ～３０ｄ介入治疗１次。结果全组４２例共用密钙息１疗程２８例，２疗程８例，３疗程５例，４疗程１例。ＣＲ４例，ＰＲ２８例，止痛有效率为（ＣＲ＋ＰＲ）７６．１％（３２／４２）。治疗前活动能力Ⅰ级＋Ⅱ级为１７例，治疗后为２９例，活动能力有效率为７０．５％（１２／１７）。４２例病人介入治疗前共有骨转移灶总数１６８个，介入治疗共进行１４７例次，每例平均３．５次，治疗后病灶总数减为１４７个，参照实体瘤疗效标准统计ＣＲ６例，ＰＲ１４例，总有效率（ＣＲ＋ＰＲ）为４７．６％（２０／４２）。结论密钙息与骨转移灶供血动脉介入化疗，既能明显缓解骨癌造成的剧痛，同时使转移灶缩小，不失为晚期骨转移癌一种有效治疗手段。
Objective To discuss the clinical therapeutic effect of combined miacalcic and interventional
chemotherapy in bony metastatic carcinoma. Methods To 42 patients of bony metastatic
carcinoma, miacalcic was given with 100 IU (M) q.d7 days, and with percutaneous artery
(supplying bony metastasis) catherized into chemotherapy drugs. Interventional chemotherapy
was given every 2030 days. Results In all 42 cases,28 were given with 1 course of treatment,8
cases with 2, 5 cases with 3 and 1 case with 4.In this group, 4 CR and 28 PR were achieved.
The analgesic effective rate (CR+PR) was 76.1%(32/42). Before treatment,grade and mobility
werein 17 patients.After treatment, it became 29. The effective rate of mobility was 70.5%(12/17).
Before therapy,there were 168 bony metastasis in 42 patients. 147 times of interventional
chemotherapy were given, 3.5 times for one in average. After therapy,the quantity of metastasis
decreased to 147. 6 CR and 14 PR were achieved. The effective rate (CR+PR) was 47.6%(20/42t
to late stage bony metastatic carcinoma. ). Conclusion The combined treatment of miacalcic
and interventional chemotherapy in the medium and late stage bony metastatic carcinoma can
significantly relieve the serious ache caused by osteocarcinoma and shrink the metastasis, so
it was an effecfive treatmen
出处
《肿瘤研究与临床》
CAS
1999年第3期168-170,共3页
Cancer Research and Clinic
关键词
骨转移癌
密钙息
介入化疗
Bony metastatic carcinowaMiacalcicInterventional
chemotherapy
