摘要
目的急性混合细胞白血病（mixed acute leukemia,MAL）的治疗缓解率低,复发率高,探讨粒细胞集落刺激因子（granulocyte-colony stimulating factor,G-CSF）联合高三尖杉酯碱或阿克拉霉素和小剂量阿糖胞苷的预激化疗方案治疗MAL的临床疗效。方法共8例MAL患者,男5例,女3例,采用预激方案治疗。给予小剂量阿糖胞苷10 mg/（m2.d）,第1天至第14天,每12 h皮下注射;阿克拉霉素20 mg/d,第1天至第4天,静脉输注。或高三尖杉酯碱1 mg/（m2.d）,第1天至第7天,静脉输注;G-CSF 100~200μg/（m2.d）,第1天至第14天,皮下注射。结果 4例患者经治疗完全缓解,2例部分缓解,总有效率为75%。治疗中患者主要表现为粒细胞缺乏、血小板减少、继发感染及发热等,无严重不良反应。结论预激方案治疗MAL疗效较好,不良反应小,为进一步治疗争取时间。
Objective The treatment of acute mixed-lineage leukemia is characterized by a low rate of remission and a high rate of recurrence.This study was to investigate the clinical effect of the granulocyte-colony stimulating factor（G-CSF） combined with homoharringtonine or aclacinomycin and low-dose ara-C in the treatment of acute mixed-lineage leukemia.Methods Eight patients with acute mixed-lineage leukemia,5 males and 3 females,received priming chemotherapy,with subcutaneous injection of ara-C at 10 mg/（m2/d） every 12 hours on day 1-14 and intravenous injection of aclacinomycin at 20 mg/d on day 1-4,or intravenous injection of homoharringtonine at 1 mg/（m2/d） on day 1-7 and subcutaneous injection of G-CSF at 100-200 μg/（m2/d） on day 1-14.Results Complete remission was achieved in 4 and partial remission in 2 of the patients,with a total remission rate of 75%.Apart from mild agranulocytosi,thrombocytopenia,secondary infection,and fever,no serious adverse reactions were found during the treatment.Conclusion Priming chemotherapy has a good effect and mild adverse reactions in the treatment of acute mixed-lineage leukemia.
出处
《医学研究生学报》
CAS
2010年第9期960-961,共2页
Journal of Medical Postgraduates
