摘要
目的:观察慢性紫外线照射对皮肤屏障功能及光老化进程的影响。方法:156例杭州地区健康志愿者分别在项部、手背、锁骨周围前胸部位(曝光部位)和腰部、臀部、腹部(非曝光部位)接受检测。以多功能皮肤测试仪MPA 9的CM 825探头进行皮肤含水量检测,以TM 300探头进行皮肤经皮水分丢失量(transepidermalwater loss,TEWL)检测,RVM 600探头检测皮肤弹性(Ur/Uf值),激光多普勒血流仪(laser doppler flowmetry,LDF)检测皮肤相对血流量(PU)。结果:>50岁组曝光部位的皮肤含水量(12.78±2.36)较非曝光部位(23.68±3.24)明显减少(P=0.036)。>50岁组曝光部位的TEWL水平最高(12.98±2.86)g.m-2.h-1。各年龄段曝光部位皮肤的TEWL均较非曝光部位高,但并无统计学差异(P>0.05)。>50岁组曝光部位皮肤的皮肤弹性Ur/Uf值低至(0.11±0.07),较非曝光组(0.32±0.1)明显降低(P=0.028)。各年龄组曝光部位的PU值与非曝光部位相比无统计学差异。结论:曝光部位、>50岁组健康人群的皮肤相对血流量无明显增长,但含水量降低,TEWL升高,皮肤弹性下降,表明慢性紫外线照射可损伤皮肤屏障功能,从而促进光老化进程。
Objective： To investigate the effect of chronic ultraviolet（UV） exposure on skin barrier function and photoaging process.Methods： One hundred and fifty-six volunteers from Hanghzou areas were enrolled in the study.UV-exposed skin areas（neck,dorsum of hand or frontier chest） and UV-unexposed areas（waist,buttock or abdomen） were tested.Probe CM 825 of skin multi-functional detector MPA9 was applied to test the skin water content;probe TM 300 was applied to test transepidermal water loss（TEWL） and probe RVM 600 was applied to detect skin elasticity（Ur/Uf）.Relative perfusion unit（PU）of the skin was detected by laser doppler flowmetry（LDF）.Results： Skin water content value at UV-exposed skin areas was 12.78±2.36 in elderly group（50y）,which was significantly lower than that of UV-unexposed skin areas（23.68±3.24,P=0.036）.Highest level of TEWL（12.98±2.86） g·m-2·h-1 was detected at UV-exposed areas in elderly group;there were trends of increasing TEWL levels at UV-exposed areas than at UV-unexposed areas in all age groups,however,there were no statistical differences（P0.05）.The elasticity of Ur/Uf value at UV-exposed skin areas in eldely group was 0.11±0.07,which was remarkably lower than that of UV-unexposed skin areas（0.32±0.1,P=0.028）.No significant difference of skin perfusion was observed between UV-exposed and UV-unexposed areas.Conclusion： Chronic exposure to UV may damage skin barrier function and therefore play a role in skin photoaging process.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2010年第5期517-522,共6页
Journal of Zhejiang University(Medical Sciences)
基金
中华医学会--薇姿皮肤医学研究项目(2008)
关键词
皮肤/辐射效应
紫外线
皮肤衰老
弹性
Skin/radiation effects
Ultraviolet rays
Skin aging
Elasticity
