摘要
目的观察光动力疗法（PDT）联合AVASTIN玻璃体腔注射治疗高度近视性黄斑区脉络膜新生血管（CNV）的临床效果。方法经眼底荧光血管造影（FFA）和吲哚青绿（ICGA）检查确诊为高度近视性黄斑区CNV患者26例26只眼，非随机选取12例12只眼仅行光动力疗法，14例14只眼先行AVASTIN 1．25mg玻璃体腔注射，1周后行光动力治疗，治疗后1、3、6个月复诊，记录最佳矫正视力、症状变化、FFA及黄斑区的情况，对治疗前1天和治疗后6个月的最佳矫正视力、自觉症状进行比较分析。结果6个月后，Amsler方格表检查PDT组4只眼症状消失，6只眼减轻或不变，2只眼加重；联合治疗组7只眼症状消失，6只眼减轻或不变，1只眼加重。最佳矫正视力，PDT组6只眼视力提高1行以上，4只眼视力不变，2只眼视力下降l行以上；联合治疗组10只眼视力提高1行以上，3只眼视力不变，1只眼视力下降1行以上。2组患者在消除或减轻症状、提高或稳定视力等方面进行组间Fisher精确检验，P〉0．05，差别均无统计学意义。结论光动力疗法联合AVASTIN玻璃体腔注射治疗治疗高度近视性黄斑区CNV．在消除或减轻患者的自觉症状、提高或稳定患者的视力方面，较单纯光动力疗法（PDT）均无明显差别．
Objective To evaluate best-corrected visual acuity and symptoms outcomes of photodynamic therapy （PDT） combined with intravitreal Bevacizumab （Avastin） injection in patients with subfoveal choroidal neovascularisation （CNV） caused by high myopia. Methods Prospective, non-random, interventional study. Twenty-six patients （26 eyes） with subfoveal CNV secondary to high myopia were diagnosed by fimdus fluorescein angiography and indocyanine green angiography. Twelve of 26 eyes were treated with a standard regimen of PDT with verteporfin, and 14 of 26 eyes were treated with a standard regimen of PDT combined with intravitreal Avastin （1.25mg）. Injection was given 1 week before PDT. The follow-up schedule were 3 and 6 months after PDT, the tests including best-corrected visual acuity, symptoms of Amsler grid and FFA were repeated on each follow-up visit. The eyes improvement of best-corrected visual acuity and relief of symptoms were analyzed. Results Six months after PDT, as to the symptoms of Amsler grid, 4 eyes of PDT group completely disappeared, 6 eyes relieved or stable and 2 eyes worsened; 7 eyes of PDT combined with Avastin group completely disappeared, 6 eyes relieved or stable and 1 eyes worsened. As to the best-corrected visual acuity, 6 eyes of PDT group improved or more than 1 line, 4 eyes remained stable and 2 eye decreased more than 1 line; 10 eyes of PDT combined with Avastin group improved or more than 1 line, 3 eyes remained stable and 1 eye decreased more than 1 line. Fisher exact test was used to compare the difference between 2 groups BCVA improvement and relief of symptoms, P 〉0.05, and no significant difference. Conclusions There is no difference between PDT and PDT combined with intravitreal Avastin Injection in BCVA improvement and relief of symptoms for subfoveal choroidal neovascularization of high myopia.
出处
《中国实用眼科杂志》
CSCD
北大核心
2010年第9期1009-1011,共3页
Chinese Journal of Practical Ophthalmology
