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脑钠肽检测对围产期心肌病的鉴别诊断价值

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摘要 目的 探讨检测脑钠肽(BNP)对围产期心肌病心衰患者的鉴别诊断价值.方法 妊娠并呼吸困难患者62例,其中围产期心肌病者46例,非心肌病者16例,荧光免疫法测定血浆BNP,心脏超声和右心漂浮导管法分别测定心脏左室射血分数(LVEF)和肺毛细血管楔压(PCWP).结果 (1)围产期心肌病患者血浆BNP水平明显高于非心肌病患者.(2)以100 pg/ml为正常参考值,BNP诊断心衰的敏感性为93.4%(43/46),特异性93.75%(15/16),排除心衰的阴性预测价值93.5%(58/62).(3)心衰患者BNP水平与PCWP呈正相关(r=0.46,P<0.01),与LVEF成负相关(r=-0.62,P<0.01).结论 荧光免疫法检测BNP诊断围产期心肌病敏感而且特异,可作为妊娠合并呼吸困难鉴别诊断的一个观察指标.
出处 《中国医师杂志》 CAS 2010年第9期1263-1264,共2页 Journal of Chinese Physician
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