摘要
目的:观察羟考酮控释片单药或联合加巴喷丁治疗癌性神经病理性疼痛的镇痛效果。方法:入组患者第一周先予羟考酮控释片单药止痛;第8日轻度疼痛以下者入A组,继续单药治疗2周,中至重度疼痛者入B组,联合加巴喷丁止痛2周。结果:共入组63例,58例(92.06%)完成第一周治疗;第8日22例(37.93%)入A组,36例(62.07%)入B组,两组患者第15日疼痛程度均明显减轻,但第22日都无显著改善。A组第15、22日羟考酮控释片的平均剂量分别为71.43mg及81.90mg(P=0.004);B组第15、22日加巴喷丁的平均剂量为(862.50mg,993.75mg,P<0.001)。便秘为最常见副反应,A、B两组的发生率分别为13.64%及14.26%。结论:羟考酮控释片单药对部分神经病理性疼痛有效;单药疗效不满意时,联合加巴喷丁可能有效;两药的副作用可防治。
Objective： To evaluate the analgesic efficacy of controlled-release（CR） oxycodone and gabapentin in malignant neruopathic pain（NP）.Methods： Patients with malignant NP were enrolled and initially took one week CR oxycodone.Pain intensity（PI） was reevaluated at the 8th day.Patients with mild pain were allocated to group A.And they took CR oxycodone for another two weeks.Patients with moderate to severe pain were allocated to group B and were added gabapentin.Results： 63 patients were enrolled and 58（92.06%） completed the initial week＇s therapy.22（37.93%） were allocated to group A and 36（62.07%） patients were allocated to group B.PI was significantly reduced at the 15th day in both group A and B,but was not reduced at the 22nd day.Mean daily dose（MDD） of CR oxycodone at the 15th and 22nd day,were 71.43 mg and 81.90 mg（p = 0.004） in group A,respectively.MDD of gabapentin at the15th and 22nd day were 862.50 mg and 993.75 mg（P〈0.001）,respectively.Constipation was the most common side effects and occurred in 13.64% patients in group A and 14.26% in group B.Conclusions： Malignant NP may be well controlled by CR oxycodone mono-therapy.Combination with gabapentin is sensible when pain was not satisfactory relieved by it alone.Side effects of the two drugs are manageable.
出处
《中国疼痛医学杂志》
CAS
CSCD
2010年第5期276-279,共4页
Chinese Journal of Pain Medicine
