摘要
目的评价快速试纸法检测尿胰蛋白酶原-2对小儿急性胰腺炎(AP)的诊断价值。方法收集以急性腹痛和(或)呕吐为主诉入院的33例患儿的血液及尿液标本,分别检测其尿胰蛋白酶原-2、血淀粉酶、尿淀粉酶及血脂肪酶。参考2004年中国急性胰腺炎诊治指南(草案)推荐的诊断标准,将患儿分为AP组(17例)和非AP组(16例)。比较二组上述4项检测指标的阳性率及敏感性、特异性、阳性预测值、阴性预测值及准确度。应用SPSS13.0软件进行统计学分析。结果 AP组尿胰蛋白酶原-2、血淀粉酶、尿淀粉酶及血脂肪酶的阳性率明显高于非AP组,差异均有统计学意义(Pa<0.01)。尿胰蛋白酶原-2诊断AP的敏感性、特异性、阳性预测值、阴性预测值及准确度分别为88.24%、100.00%、100.00%、88.89%和93.94%。结论快速试纸法检测尿胰蛋白酶原-2具有早期、简便、准确、快速等优点,较血淀粉酶、尿淀粉酶和血脂肪酶更具有诊断优势,是诊断小儿AP的一个非常有价值的诊断方法。
Objective To evaluate the clinical value of urinary trypsinogen-2 detected by rapid dipstick method in the diagnosis of acute pancreatitis（AP）in children.Methods Serum and urine samples of 33 children with acute abdominal pain and（or）vomiting were co-llected to detect urinary trypsinogen-2,serum amylase,urine amylase and serum lipase.Thirty-three children were divided into AP group（17 cases）and non-AP group（16 cases）according to diagnostic and therapeutic guidelines（draft）of China in 2004.The positive rate of the four parameters between AP group and non-AP group,and the sensitivity,specificity,positive and negative predictive value and accuracy of the four parameters were analyzed.SPSS 13.0 software was used to analyze the data.Results The positive rate of urinary trypsinogen-2,serum amylase,urine amylase and serum lipase in AP group were higher than those in non-AP group,there were significant differences between the 2 groups（Pa0.01）.The sensitivity,specificity,positive and negative predictive value and accuracy of urinary trypsinogen-2 dipstick detection in diagnosing AP in children were 88.24%,100.00%,100.00%,88.89% and 93.94%,respectively.Conclusions Detecting urinary trypsinogen-2 with rapid dipstick is early,simple,accurate and rapid.This method has more diagnostic advantages than serum amylase,urine amylase and serum lipase.It is a very valuable diagnostic method for AP in children.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2010年第19期1492-1493,共2页
Journal of Applied Clinical Pediatrics
