摘要
目的评价免疫层析法检测尿胰蛋白酶原-2在急性胰腺炎(acute pancreatitis,AP)中的应用价值。方法对134例急性腹痛病例进行尿胰蛋白酶原-2及血、尿淀粉酶的检测,并比较其敏感性、特异性、阴性预测值、阳性预测值及准确度。结果30例AP患者中28例尿胰蛋白酶原-2阳性,敏感性为93.3%,血清淀粉酶检测的敏感性为86.7%(26/30),尿淀粉酶检测的敏感性为83.3%(25/30);104例其他急腹症中,8例尿胰蛋白酶原-2阳性,特异性为92.3%。血清淀粉酶检测的特异性为87.5%(91/104);尿淀粉酶检测的特异性为85.6%(89/104)。尿胰蛋白酶原-2检测敏感性、特异性、阴性预测值、阳性预测值及准确度均最高,但三者之间差异无显著性(P>0.05)。结论尿胰蛋白酶原-2是急腹症患者筛选AP快速而简便的方法,具有较高的特异性和敏感性。
Objective To evaluate the diagnostic value of urinary trypsinogen-2 in screening acute pancreatitis. Methods Urinary trypsinogen-2, serum and urinary amylase were tested in 134 patients with acute abdominal pain. The sensitivity, specificity, positive and negative predictive value and accuracy were analyzed. Results Urinary trypsinogen-2 was positive in 28/30 patients with acute pancreatitis, the sensitivity was 93.3%. The sensitivity of serum amylase and urinary amylase were 86.7% （26/30） and 83.3% （25/30）. Eight patients with false positive test result were found in 104 patients without acute pancreatitis. The specificity of serum amylase and urinary amylase were 87.5% （91/104） and 85.6% （89/104）. Urinary trypsinogen-2 had higher sensitivity, specificity, positive and negative predictive value and accuracy among the above three parameters. However, no significant difference was found among them （P 〉 0.05）. Conclusion Detection of urinary trypsinogen-2 is a convenient and rapid diagnostic method with high sen- sitivity and specificity for screening acute pancreatitis in patients with acute abdomen.
出处
《胃肠病学和肝病学杂志》
CAS
2009年第7期665-667,共3页
Chinese Journal of Gastroenterology and Hepatology
