摘要
轻度认知功能障碍(MCI)是介于正常老化和痴呆之间的一种临床状态。根据认知领域损害的类型和数量将MCI分为4个亚型,即遗忘型;伴记忆障碍的多个领域型;无记忆障碍的单一领域型;无记忆障碍的多领域型。MCI可转化为阿尔茨海默病(AD)或其他痴呆、可停留在认知障碍阶段、有些患者认知可恢复正常。遗忘型MCI可能为AD的早期表现,而非遗忘型MCI更有可能发展为其他类型的痴呆如血管性痴呆、额颞叶痴呆或Lewy小体病性痴呆。多领域型MCI特别是伴记忆障碍的多领域型MCI其转化为AD的可能性最高,而单一领域型MCI(遗忘型和非遗忘型)常转化为正常认知状态。但目前对MCI的治疗或预防MCI向痴呆的转化尚无有效方法。许多方法正处在研究阶段,其效果有待进一步确认。
Summary： Mild cognitive impairment （MCI） is thought to represent a transitional state between normality and dementia. Based on the domains of impairment, MCI can be divided into 4 subtypes, namely Amnestic MCI single domain, Amnestic MCI multiple domain, Nonmnestic MCI single domain and Non-amnestic MCI multiple domain. MCI may progress to Alzheimer＇s disease （AD） or other dementia, remain in MCI, return to normal cognitive state. Amnestic MCI seems to represent an early stage of AD, while the outcomes of the Non-amnestic MCI subtypes appear more heterogeneous--including vascular dementia, frontotemporal dementia or dementia with Lewy bodies. Multiple-domain MCI especially Amnestic MCI multiple domain is of the highest rate of conversion to AD, Single-domain MCI （amnestic and non-amnestie） more frequently returns to normal cognitive state. Currently there is no effective therapy of MCI and no way to prevent its conversion to AD. Many therapies are underway,but the result remains unclear
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2010年第10期894-896,共3页
Chinese Journal of Practical Internal Medicine
关键词
轻度认知障碍
痴呆
转化
mild cognitive impairment
dementia
conversion
