摘要
目的：观察胺碘酮，美西律，普罗帕酮有效治疗室性心律失常前后QT离散度（QTd）的变化。方法：采用随机、单盲的方法，测定3组病人用药前及用药后一周或两周的QTd．QTCd及RR间期．结果：用药前3组的QTd．QTcd及RR间期无显著性差异（P＞0.05）。用药后按碘酮组的QTd，QTcd明显降低（QTd37±15ms与21±9ms，QTcd41±17ms与23±10ms．P＜0．05），RR间期明显延长；美西律及普罗帕酮组用药前后QTd，QTcd．RR间期无显著性变化（P＞0．05）。用药后胺碘酮组的QTd．QTcd显著小于别外两组（QTd21±9ms与35±8ms，37±13ms，QTcd23±16ms与39±11ms，39±14msP＜0．05））；但RR间期显著长于另两组。结论：治疗室性心律失常有效者胺碘酮降低QT离散度．而美西律，普罗帕酮对QT离散度无显著影响。
objective: To investigate the effects of amiodarone, maxiletine and propafenone on Variation of QT dispersion (QTd) in patients,with ventricular arrhythmias before and after effective treatment. Metbodst: A random, single-blind and respective study as Performed in 59 petieuts. The QTd, QTcd and RR interval were measured before and one or two weeks after the treatwent of amiodarone(n=26). mexiletine (n=20) and propafenone (n=13). Results : No significant differences of QTd, QTcd and RR interval were found in the three groups before drugg tberapy: The QTd and QTcd were obviously decreased in amiodarone group but RR interval,as increased on the contrary (QTd37±15ms vs 21±9ms, QTcd 41±17ms vs 23±10ms, P<0. 05). There were no significant differences of QTD, QTcd and RR interval in the other two groups (P>0. 05); The QTd and QTcd in amiodarone group,ere obviously icwer than that of mexiletine or propafenone group after treatment (QTd 21±9ms vs 35±13ms, 37±13ms, QTcd 23±10ms vs 39±11ms. 39±14ms, P<0. 05) but the RR interval was higher. Conclusion: In the patients with ventricular arrhythmias treated effectively amiodarone decreased QT dispersion, but mexiletine and propafeone hadno obvious influences on QT dispersion.
出处
《镇江医学院学报》
1999年第2期196-197,共2页
Journal of Zhenjiang Medical College
