摘要
观察了糖尿病肾病(DN)与单纯糖尿病(DM)患者血中总超氧化物歧化酶(T-SOD)及脂质过氧化物代谢产物丙二醛(MDA)水平变化,结果表明:各期DN组SOD活力均明显低于单纯Ⅱ型DM组(P<0.01),SOD/MDA在终末期DN组最低,该组SOD活力低于早、中、期DN组(P<0.05)。提示终末期DN对过氧化损伤存在易感性,过氧化损伤可能是参与DN发生、发展的病理生理学基础,机体抗氧化系统活力降低决定了终末期DN对过氧化损伤的易感性。
An observation was made of the alterations of various stags of diabetic nephropathy(DN)and the defensive functon of typeⅡdiabetes mellitus against lipid peroxide trauma so as to determine superoxide dismutase(T-SOD)levels,the metabolite of lipid peroxide MDA levels,SOD/MDA in blood of various stage DN and typeⅡdiabetes.The results showed:the activities of T-SOD、SOD/MDA were all lower in early metaphase end period DN than those of single typeⅡdiabetes mellitus(P<0.01)but significantly reduced in the end stage of DN、MDA were significantly increased than not in the middle period(P>0.05).The results showed that the patients of end stage DN there was significant susceptibility by lipid peroxide trauma,this is a pathophysiology from early stage DN to end stage DN.the decrease in activities of SOD plays an important role.
作者
孙苏欣
范幼筠
周毅
Sun Suxin;Fan Youyun;Zhou Yi(Department of Intermal Medicine,Seoond Affliated Hospital,Hubei Medical University,Wuhan 430071,China)
