6Rulifson EJ,Wu CH,Nusse R.Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless[J].Mol Cell,2000,6(1):117-126.
7Rawadi G,Vayssière B,Dunn F,et a1.BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop[J].J Bone Miner Res,2003,18(10):1842-1853.
8Westendorf JJ,Kahler RA,Schroeder TM.Wnt signaling in osteoblasts and bone diseases[J].Gene,2004,341:l9-39.
9Boyden LM,Mao J,Belsky J,et al.High bone density due to a mutation in LDL-receptor-related protein 5[J].N Engl J Med,2002,346(20):1513-21.
10Kato M,Patel MS,Levasseur R,et al.Cbfa1-independent decrease in osteoblast proliferation,osteopenia,and persistent embryonic eye vascularization in mice deficient in Lrp5,a Wnt coreceptor[J].J Cel Bio,2002,157(2):303-314.
2Holmen SL, Giambernardi TA, Zylstra CR, et al. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res, 2004, 19(12) : 2033-2040.
3Kato M, Patel MS, Levasseur R, et al. Cbfal-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol, 2002, 157(2) : 303-314.
4Fujino T, Asaba H, Kang MJ, et al. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci USA, 2003,100( 1 ) :229-234.
5Little RD, Carulli JP, Del Mastro RG, et al. A mutation in the LDL receptorrelated protein 5 gene results in the autosomal dominant high- bone-mass trait. Am J Hum Genet, 2002, 70(1) : 11-19.
6Van Wesenbeeck L, Cleiren E, Gram J, et al. Six novel missense mutations in the LDL receptorrelated protein 5 (LRP5) gene in different conditions with an increased bone density. Am J Hum Genet, 2003, 72(3) :763-771.
7Bennett CN, Longo KA, Wright WS, et al. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci USA, 2005, 102(9): 3324-3329.
8Babij P, Zhao W, Small C, et al. High bone mass in mice expressing a mutant LRP5 gene. J Bone Miner Res, 2003, 18(6) : 960- 974.
9Yu HM, Jerehow B, Sheu TJ, et al. The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development, 2005, 132 (8) : 1995-2005.
10Harwood AJ. Regulation of GSK-3: a cellular multiprocessor. Cell, 2001, 105(7): 821-824.
1Vatsa A, Breuls RGb, Semeins CM, etal. Osteocyte morphology in fibula and calvaria-Is there a role for mechanosensing? [J]. Bone, 2008, 43 (3):452-458.
2Bakker A, Nulend JK, Burger E. Shear stress inhibits while disuse promotes osteocyte apoptosis [J]. Biochem and Biophys Res Commun, 2004, 320:1163- 1168.
3Vatsaa A, Smit TH, Nulend JK. Extracellular NO signalling from a mechanically stimulated osteocyte[J]. J of Biomech,2007, 40:S89-S95.
4Phillips JA, Almeida EAC, Hill EL, et al. Role for 13 1 integrins in cortical osteocytes during acute musculoskeletal disuse[J]. Matrix Biology, 2008, 27:609-618.
5Tan SD, Bakker AD, Semeins CM, et al. Inhibition of osteocyte apoptosis by fluid flow is mediated by nitric oxide [J]. Biochem Biophys Res Commun, 2008, 369(4):1150- 1154.
6Rath AL, Bonewald LF, Ling J, et al. Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow[J]. J Biomech, 2010, 43:1560-1564.
7Kitase Y, Barragan L, Qing H, et al. Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the 13-catenin and PKA pathways[J]. J Bone Miner Res, 2011, 26(2):439.
8Kalogeropoulos M, Varanasi SS, Olstad OK, et M. Zicl transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes[J]. FASEB J, 2010, 24(8):2893-2903.
9Adachi Tb, Aonuma Y, ho SI, et al. Osteocyte calcium signaling response to bone matrix deformation[J]. J Biomech, 2009, (42):2507-2512.
10Hung CT, Allen FD, Pollack SR, et al. Intracellular Ca^2+ stores and extracellular Ca^2+are requred in the real-time Ca2^2+ response of bone cells experiencing fluid flow[J]. Biomech, 1996, 29(11):1411-1417.
