摘要
目的探讨溃疡性结肠炎患者血清中IL-21的表达及其在溃疡性结肠炎发生、发展过程中的作用。方法收集30例经内镜证实的溃疡性结肠炎患者的血清标本，30例性别、年龄相匹配的正常人作为对照组，用酶联免疫吸附法（ELISA）检测IL-21的表达水平。结果溃疡性结肠炎组血清中IL-21表达水平与正常对照组相比明显增高（P〈0．05），并与临床上病情的严重程度相一致。结论IL-21参与了溃疡性结肠炎的发生、发展过程，并与溃疡性结肠炎病情活动性有较好相关性，可客观反映溃疡性结肠炎的炎症活动情况。
Objective To investigate the expressions ofintcrleukin-21 （IL-21） and to explore the role of those in the progression of ulcerative colitis.Methods In peripheral blood from 30 patients of ulcerative colitis and 30 normal controls, IL-21 in serum were assessed using ELISA. Results The serum levels of IL-21 was significantly higher in ulcerative colitis group than those in normal control （P〈0.05）, and these changes were corresponding to the clinical symptoms.Conclusion The expression of IL-21 may be involved in the pathogenesis of ulcerative colitis, and their levels reflect the disease activity in ulcerative colitis.
