摘要
目的观察中药复方制剂续断通络片对糖尿病大鼠神经传导速度的影响。方法采用链脲佐菌素(STZ)诱导的糖尿病大鼠模型,随机分为模型组、甲钴胺组、续断通络片低剂量组、续断通络片中剂量组和续断通络片高剂量组,给予续断通络片(生药)灌胃,以甲钴胺作为对照,疗程8周,分别于给药的2、4、6、8周检测大鼠的坐骨神经传导速度。结果经续断通络片中、高剂量治疗的DM大鼠在造模8周后血糖明显下降(P<0.05),在4、6、8周均可明显改善神经传导速度(P<0.05或P<0.01),低剂量续断通络片治疗组在6周时可明显改善神经传导速度(P<0.05),余无明显差异。结论续断通络片能够改善STZ-DM大鼠的神经传导速度,各个剂量及各个时间均有较为明显的改善,显示续断通络片对糖尿病大鼠周围神经病变有明显改善作用。
Objective To observe the impact of Xu Duan Tong Luo Pian（XDTLP） on nerve conduction velocity（NCV） of experimental diabetic peripheral neuropathy（DPN） rats. Methods Diabetic rats were induced by STZ celiac injection. Then, the rats which successfully became diabetic model were divided into diabetic model group. Methycobal was given by 0.25mg/kg.d, XDTLP was given by3.2、6.3、12.6g/kg.d herb according to low, middle and high dose, which lasted 8 weeks. Results After treatment with XDTLP for 8 weeks, NCV increased greatly. Conclusion The experiment showed that XDTLP can significantly improve the nerve conductive velocity in rats with DPN.
出处
《中国药物警戒》
2010年第10期577-579,共3页
Chinese Journal of Pharmacovigilance
关键词
续断通络片
糖尿病周围神经病变
实验研究
Xu Duan Tong Luo Pian
diabetic peripheral neuropathy
experimental research
