摘要
ＣＤ３单克隆抗体（ＣＤ３ＭｃＡｂ）对Ｔ细胞具有强烈的丝裂原作用。本文显示将ＣＤ３ＭｃＡｂ联合ＩＬ－２激活的杀伤细胞（ＣＤ３ＡＫ）对人急性白血病新鲜细胞和Ｋ５６２细胞均有明显杀伤作用。正常人ＣＤ３ＡＫ细胞对各型急性白血病杀伤活性无差别；正常人与白血病缓解期的ＣＤ３ＡＫ细胞杀伤力类同，且自体与异体亦无区别；但是，复发期ＣＤ３ＡＫ细胞杀瘤作用明显减弱。
CD3 monoclonal antibody has mitogenetic activity on T cells.This study demonstrated that the antiCD3activited killer cells (CD3AK) have significant killing activity on freshly isolated human acute leukemia cells and cell line K562.There was no significant difference between the killing rate of CD3AK from normal donor on different types of leukemia.The killing activity of CD3AK from patients in remission was similar to normal donor.However from relapse patients ,it was significantly decreased .There was no impact of blood groups on killing activity of CD3AK.
出处
《西安医科大学学报》
CSCD
1999年第2期219-222,共4页
Journal of Xi'an Medical University(Chinese)
