摘要
目的：探讨膀胱癌、肾细胞癌突变型ｐ５３蛋白的高表达与预后之间的关系。方法：采用免疫组化ＡＢＣ法分别对４０例膀胱癌和３４例肾细胞癌组织标本进行ｐ５３ 蛋白表达的研究。结果：膀胱癌、肾细胞癌突变型ｐ５３ 基因癌蛋白的高表达阳性率为３７．５％ 和３２．４％ ，而正常肾组织及空白对照均为阴性。膀胱癌ｐ５３ 阴性、阳性患者的５年生存率分别为８４．０％ 、６６．７％ ，两组比较无显著性差异（Ｐ＞ ０．０５）。肾癌ｐ５３ 蛋白表达阴性、阳性患者的５ 年存活率分别为６９．６％ 、２６．６％ ，两组比较无显著性差异（Ｐ＞ ０．０５）。结论：提示ｐ５３ 基因高表达可能成为恶性肿瘤标志之一。突变型ｐ５３ 基因表达可能与膀胱癌、肾细胞癌的预后无关。
Objective: To study the relativity between expression of mutant type of p53 in bladder cancer and in renal adenocarcinoma and their prognosis. Methods: With ABC immunohistochemical technique, expressions of p53 protein was immunohistochemically analysed in cases of bladder cancer and 34 renal adenocarcinomas with Known follow up data. Results: p53 protein was expressed in 32.4% of bladder cancer and in 35.5% of the renal adenocarcinoma, and the control of normal renal tissue wasn't expressed. The 5 year survival rates for the positive cases and for negative cases were 84.0% and 66.7% respectively in bladder cancer (P>0.05). The 5 year survival rates for the positive cases and for the negative cases were 26.6% and 69.6% respectively in renal adenocarcinomas (P>0.05). Conclusion: The result showed that the overexpression of mutant type of p53 might become one of the adjuvant markers for malignancy. It is suggested that the overexpression of mutant type of p53 may have no relation to the prognosis in bladder cancer and in renal andenocarcinoma.
出处
《新疆医科大学学报》
CAS
1999年第2期102-104,共3页
Journal of Xinjiang Medical University
关键词
膀胱癌
肾细胞癌
P53蛋白
预后
bladder cancer
renal adenocarcinoma
p53 protein
prognosis
