摘要
目的：进一步探讨血小板活化因子（ＰＡＦ）在烧伤后肠粘膜屏障损害中的作用机制。方法：在大鼠３０％Ⅲ度烫伤模型上，观察ＰＡＦ拮抗剂ＷＥＢ２１７０对烧伤后肠粘膜血流量、肠粘膜内ｐＨ（ｐＨｉ）和肠组织含水量的影响。结果：烫伤后肠粘膜血流量和ｐＨｉ较对照组显著降低，而肠组织含水量显著增多。应用ＰＡＦ拮抗剂ＷＥＢ２１７０治疗能有效改善烫伤后肠粘膜血流量，提高肠粘膜ｐＨｉ，并有效降低肠组织含水量，从而明显减轻肠粘膜病理损害。结论：ＰＡＦ是导致烧伤后肠粘膜微循环障碍的重要因素之一。
Objective: To investigate the effects and their mechanism of platelet activating factor
(PAF) antagonist on the intestinal mucosal microcirculation after scalding in rats. Methods: The
changes of intestinal mucosal blood flow, intestinal intramucosal pH (pHi) and intestinal water
content were determined on rats suffering from 30% TBSA third degree scalding and treated with
PAF antagonist WEB2170. Results: PAF antagonist treatment of the scalded rats could
significantly increase intestinal mucosal blood flow and pHi, decrease intestinal water content
and alleviate evidently the intestinal mucosal damages as compared with those of the control
group. Conclusion: PAF is one of the important factors to result in postburn disturbance of
intestinal mucosal microcirculation.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1999年第5期329-331,共3页
Journal of Third Military Medical University
基金
国家自然科学基金
关键词
血小板活化因子
肠粘膜
烧伤
微循环
platelet activating factor
intestinal mucosa
blood flow
intramucosal pH
burns
rat
