摘要
本文以上午8时血清皮质醇浓度、皮质醇昼夜节律及2小时ACTH试验三项指标对54例单纯性肾病患儿的肾上腺皮质功能进行了测定。结果表明:患儿组上午8时血清皮质醇浓度明显低于正常对照组;无论激素治疗前治疗后,均有部分患儿存在皮质醇昼夜节律的紊乱及肾上腺皮质储备功能的低下。提示肾上腺皮质功能低下可能在单纯性肾病的发病中起重要作用。
Adrenal cortical function was systematically detected in 54 children with steroid responsive nephrotic syndrome (SRNS)Parameters representing adrenal cortical function consisted of baseline cortisol level, carcadian rhythm of cortisol secretion and 2-hour ACTH test. The results showed: The mean value of 8Am cortisol level was significantly lower in test group than control group;A part of these children had subnormal response to ACTH test and disturbance in circadian rhythm no matter whether prednisone had used or not. It is suggested that the lower adrenal cortical function may be one of the pathogenic factors of SRNS.
