摘要
44例单纯性肾病患儿.随机分为强的松治疗单剂组和分剂组,单剂组共19例,其中男14例,女5例,年龄(X±s)为7.21±3.52;分剂组共25例,其中男18例,女7例,年龄为7.54±4.24.强的松按每2mg/(kg·d)给予,单剂组为早晨一次顿服,分剂组则分3~4次服。从第5周开始,按2mg/(kg·d),隔日早晨一次顿服。两组减量方法相同。临床研究表明,两组诱导缓解时间较为接近,诱导缓解时间单剂组为10.81±3.61d,分剂组为11±3.89d(P>0.05).但每日单剂组的柯兴氏征、高血压及食欲亢进等药物副作用明显低于每日分剂组。说明单剂组疗效相同,但药物副作用少,值得临床推广使用。
children with simple nephrotic syndrom were divided randomy l into 2 groups,One for treatment using predison[2mg/(kg.d)]once per day(19 case,male 14,female 5,aged 7.21±3.52).Another for treatment using prednison 3 times per day(25 cases,male 18,female7,aged 7.54±4.24).The same dose of prednison[2mg/(kg.d)]was administered every other morning by 2 groups 5 weeks after the intial treatment,the mean induced remission time of the groups was comparable(P>0.05)which 10.81±3.61 days for the singledosedaily administered prednison group and 11±3.89 days for the divided-dose daily-administered prednison group.The single-dose group showed much less steroid toxicity(ie cushingsid changes,hypertension,bulimia)than the divided-dose group.The method of adminstration once per day is of clinical value.
作者
李祥民
李志骏
程志刚
Li Xiangmin;Li Zhijun;Cheng Zhigang(Department of Pediatrics,First Affiliated Hospital,Hubei Medical University,Wuhan 430060,China)
