摘要
目的探讨大鼠急性脑缺血再灌注损伤时血浆及丘脑下部心钠素含量的变化。方法用血管闭塞法制备大鼠脑缺血再灌注模型，应用放免分析法检测Ｗｉｓｔａｒ大鼠急性脑缺血再灌注后血浆、丘脑下部心钠素（ＡＮＰ）含量变化。结果单纯脑缺血组丘脑下部ＡＮＰ含量较假手术对照组升高１倍以上，血流再灌注后，ＡＮＰ含量进一步增加，但不显著，而血浆中ＡＮＰ含量各组间比较无统计差异。结论丘脑下部ＡＮＰ参与脑缺血再灌注损伤过程，而血浆中ＡＮＰ含量不能反映病情。
Changes of ANP in plasma and hypothalamus after acute cerebral ischemia
reperfusion were studied.The results indicate that the ischemia group as compared with the
sham operated group that the ANP in hypothalamus increase a more than double after
postreperfusion period.There is no statistical difference about the content of ANP in plasma.It is
suggested that the ANP in hyposthalamus is related with injury after cerebral
ischemia/reperfusion,but ANP in plasma does not reflect the anomaly of CNS.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1999年第3期178-179,共2页
Chinese Journal of Gerontology
