摘要
目的探讨Ａｌｚｈｅｉｍｅｒ病（ＡＤ）患者认知功能和脑功能区的血流改变及其两者之间的关系。方法４０名ＡＤ患者、３５名年龄和性别相对应的正常老年人均予认知功能及脑ＳＰＥＣＴ检查，并做相关性研究。结果ＡＤ患者的认知功能与同年龄组老年人相比有明显减低（Ｐ＜０．００１），ＡＤ患者两侧大脑半球血流均有，但各功能区血流减低的程度不一样，其中以顶、颞、额叶、基底节血流降低的程度最为明显（Ｐ＜０．００１），丘脑、枕叶血流降低程度与对照组相比也有统计学上的差异（Ｐ＜０．０１，Ｐ＜０．０５）。相关性研究发现，ＡＤ患者语言和视觉空间障碍与左颞叶血流降低有关（Ｐ＜０．０５），注意力和记忆力的障碍则与右额叶关系密切（Ｐ＜０．０５）。结论ＡＤ患者存在认知功能障碍，其双侧大脑半球血流全面降低，且认知功能障碍与脑相关功能区低灌注密切相关。
Objective Investigation
the severity of hypoperfusion revealed by SPECT and cognitive impairments in Alzheimer
dementia(AD) patients,studying a possible relationship existing between the severity of
abnormalities of SPECT brain images and that of cognitive deficits.Methods Forty Alzheimer
disease patients and thirty five age and sex matched healthy controls were submitted to single
photon emission computed tomography(SPECT) using 99m Tc hexamethylpropyleneamine
oxime( 99m Tc HMPAO)and their cognitive functions examined.Results Symmetrical
hypoperfusion was seen in the brain cortex on SPECT images in AD group,especially in
bilateral temporal、parietal、forntal lobes( P <0 001),with significant hypoperfusion in each
occipital lobe( P <0 05).Logistic regression analysis showed that some of the SPECT regions
of interest had a significant correlation with some cognitive impairments namely verbal fluency
and visuospatioal memory significantly reliability with left temporal lobe( P <0 05),attention
and concentration with right frontal lobe( P <0 05).Conclusions The study suggests that the
distribution of brain demage could reflect symptoms in dementia and supports the validity of
analytic evaluation of dementia symptoms by cognitive functional tests.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1999年第3期132-134,共3页
Chinese Journal of Gerontology
基金
上海市1995年科技发展基金
