摘要
目的 观察丙帕他莫复合异丙酚在宫腔镜手术的临床效果和安全性.方法选择门诊宫腔镜术患者100例,ASA I~Ⅱ级,随机分成2组,每组50例.丙帕他莫组（A组）：丙帕他莫30 mg/kg＋异丙酚2 mg/kg;芬太尼组（B组）：芬太尼1 μg/kg＋异丙酚2 mg/kg.术中间断推注异丙酚维持麻醉,记录意识消失时间、术后苏醒时间、苏醒期不良反应及异丙酚用药量;呼吸和血流动力学变化;患者术中VAS评分和停药后改良OAA/S镇静评分.结果 A组意识消失时间、苏醒时间较B组明显缩短,A组的异丙酚用量少于B组,差异有统计学意义（P〈0.05）;治疗后,A组平均动脉压（MAP）较基础值明显降低（P〈0.05）,且两组MAP比较差异有统计学意义（P〈0.05）;A组、B组的呼吸暂停发生率分别为4%和18%,两组比较差异有统计学意义（P〈0.05）;A组患者停药后3、4、5 min OAA/S评分明显高于B组,差异有统计学意义（P〈0.05）;两组术中VAS评分比较差异无统计学意义（P〉0.05）.结论 丙帕他莫复合异丙酚具有麻醉起效快、苏醒快和术中血流动力学稳定等优点,更适于门诊使用.
Objective To investigate the clinical effects and safety of propacetamol and propofol during operation of hysteroscopy. Methods 100 ASA I - II patients undergoing outpatient hysteroscopy were randomly allocated into two groups. In the propacetamol group（ group A, n = 50）, anesthesia was induced by propacetamol 30 mg/kg and propofol 2 mg/kg ; whereas in the lentanyl group （ group B, n = 50 ） , anesthesia was induced by fentanyl 1 μg/kg and propdol 2 mg/kg, and was maintained with propofol when needed. The following indexes were recorded and compared in the two groups ： the time of unconsciousness, recovery time from anesthesia, the side effects during recovery and the total doses of propofol;hemodynamic and respiratory changes during anesthesia; Pain visual analog scale（ VAS ）and observers assessment of alertness/sedation（ OAA/S）. Results The time of unconsciousness and recovery time from anesthesia in group A was significantly shorter than that of group B, there was significant difference between the two groups（P 〈0. 05） ;The total doses of propofol used in group A were less than that of group B（P 〈0. 05）. After treat- ment, the MAP of group A decreased significantly （ P 〈 0.05 ） , and there was significant difference between the two groups（P 〈0. 05）. The incidence of apnea in group A and group B were 4% and 18% respectively（P 〈0. 05）. There was significant difference in the OAA/S between the two groups at 3,4,5 min after drug withdrawal （P 〈 0. 05 ）. No significant difference was found in VAS between the two groups （ P 〉 0. 05 ）. Conclusion Propacetamol and propofol anesthesia is superior for day-case hysteroscopy because of the fast onset,rapid recovery and stable hemodynamics.
出处
《实用药物与临床》
CAS
2014年第2期151-154,共4页
Practical Pharmacy and Clinical Remedies
关键词
麻醉
宫腔镜
异丙酚
丙帕他莫
Anesthesia
Hysteroscopy
Propofol
Propacetamol
