摘要
作者研究了氟碳人造血—全氟三丁胺(FC—43)乳剂对猴子骨髓造血功能的影响。恒河猴8只,用FC—43乳剂换血(25—80％),于换血后8、12个月采取骨髓液,观察骨髓造血功能。结果发现骨髓有核细胞增生活跃,粒细胞系统和红细胞系统多见,粒细胞、红细胞比例正常,巨核细胞释放血小板功能良好。各细胞系统的细胞生成、形态、发育、结构特征以及不同阶段分布率均未见明显改变。换血后8个月猴骨髓象已完全恢复。提示用FC—43乳剂给猴换血25—80％,对骨髓远期造血功能无明显影响。
The effect of perfluorotributylamine emulsion (FC-43) on myeloid hemocytopoiesis was studied in 8 Rhesus monkeies after substitution of 25-80% of monkey blood with FC-43. The bone marrow was sampled in 8 and 12 months after partial substitution of blood. The results showed obvious hypercellularity, mainly in granulocyte and erythrocyte systems. But the ratio of granulocyte to erythrocyte and release of platelets from megakaryocyte were normal. No significant change was found in the production, development, morphorlogy, structure and distribution in different stages of various cell systems. The myelogram completely recovered in 8 months after partial substitution of blood. It is suggested that FC-43 has no long term side effect on monkey myeloid hemocytopoiesis after substitution of 25-80% of blood.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
1990年第2期123-126,共4页
Journal of Biomedical Engineering
