摘要
目的回顾性分析广泛期小细胞肺癌患者转移状态对其生存的影响,以指导预后评估。方法 2003年1月至2008年12月收治134例广泛期小细胞肺癌患者,采用Kaplan-Meier法及Cox回归模式来分析患者一般情况、局部受侵情况、远处转移部位、多器官联合转移状态、转移病灶数目等因素与生存的关系。结果单因素、多因素生存分析远处转移部位与生存密切相关:肝、骨髓转移者生存期最短,中位生存期5个月;而肺转移者中位生存期最长8个月,统计学分析有明显差异(P<0.05);患者一般情况如性别、年龄、一般状况评分、局部受侵情况如有无胸水、心包积液及上腔静脉压迫综合征等及多器官联合转移状态、转移病灶数目等因素与生存期无关(P>0.05)。结论本组病例显示远处转移部位与广泛期小细胞肺癌患者生存相关。
Objective To retrospectively analyze the effect of extensive small cell lung cancer （SCLC） metastasis on survival of SCLC patients. Methods Kaplan-Meier method and Cox regression were used to analyze the relation between general condition,local invasion,distal metastasis,multiple organ metastasis,metastatic foci and survival of 134 patients with extensive SCLC metastasis,admitted to hospital from January 2003 to December 2008. Results Univariate analysis and multivariate analysis showed that the distal organ metastasis was closely related with the survival of patients with extensive SCLC metastasis （P0.05）. The survival time of SCLC patients with liver and kidney metastasis was the shortest with a median survival time （MST） of only 5 month （RR=0.423）,while the MST of those with lung metastasis was 8 months （RR=-0.450,P0.05）. The survival of SCLC patients was not related with their sex,age and general condition,local invasion （including pleural effusion and pericardial effusion）,superior vena cava compression syndrome,multiple organ metastasis,and metastatic foci. Conclusion The survival of SCLC patients is related with distal metastatic organs but not with the general condition,local invasion,multiple organ metastasis,and metastatic foci.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2010年第17期1861-1864,共4页
Journal of Third Military Medical University
关键词
广泛期
小细胞肺癌
转移
预后
extensive stage
small cell lung cancer
metastasis
prognosis
